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. Author manuscript; available in PMC: 2011 Mar 23.
Published in final edited form as: ACS Nano. 2010 Mar 23;4(3):1279–1287. doi: 10.1021/nn901297q

Figure 7.

Figure 7

Targeting gastrin receptors in an in vivo orthotopic-tumor model of pancreatic cancer. Human BxPC-3 pancreatic cancer cells were xenografted orthotopically into athymic nude mice. (A) One week following engraftment, ICG-loaded CPNPs were administered systemically via tail vein injection and near-infrared images were taken 24 hours post-injection. From left to right, mice receiving: (i) ICG-loaded, PEG-CPNPs, (ii) ICG-loaded, Gastrin- 10-PEG-CPNPs, or (iii) ICG-loaded, Pentagastrin-Avidin-CPNPs. (B) Excised, tumor-bearing, pancreases from each mouse, and excised brain (mouse ii). All images are representative of at least four independent experiment