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. Author manuscript; available in PMC: 2010 Jun 30.
Published in final edited form as: J Proteomics Bioinform. 2010 Jan 22;3(2):1–10. doi: 10.4172/jpb.1000118

Table 3.

Unique MCF7 membrane proteins enriched by hydrophobic chromatography that are not found by conventional cell membrane preparation.

Identified Proteins Accession Number Cellular Function Membrane Location
G-protein coupled receptor 123 gi|143811399 G-protein coupled receptor protein signaling pathway Cell membrane; Multi-pass membrane protein
Integrin beta-1 (Fibronectin receptor subunit β) (CD29 antigen) gi|124963 (+1) Homophilic cell adhesion, stem cell marker Sarcolemma
Nesprin-1 (Nuclear envelope spectrin repeat protein 1) gi|29839561 Anchoring protein involved in the maintenance of nuclear organization and structural integrity. Nucleus outer membrane
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PRex1) gi|148886999 Actin filament polymerization Plasma membrane
Long-chain-fatty-acid--CoA ligase 6 (LACS 6) gi|146322303 Acyl-CoA metabolism Plasma membrane
Prolow-density lipoprotein receptor-related protein 1 precursor (LRP) gi|1708865 Cell proliferation Integral to plasma membrane
Thioredoxin reductase 2 gi|34925455 Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling. Mitochondrion
Elongation factor Tu gi|1706611 Promotes the GTP-dependent binding of aminoacyl-tRNA to the Asite of ribosomes during protein biosynthesis. Mitochondrion
Polycystin-1 (Autosomal dominant polycystic kidney disease protein 1) gi|45645177 Calcium-independent cellmatrix adhesion Integral to plasma membrane
ATP-binding cassette subfamily A member 12 gi|51315963 Cell homeostasis Integral to membrane
Desmocollin-1 gi|2493422 Cell adhesion and cell junction Gap junction
Long-chain-fatty-acid--CoA ligase 6 gi|146322303 Fatty acid metabolism Mitochondrion outer membrane