Table 4A.
Selected over-expressed proteins (≥2 fold) in a triple negative breast cancer (TNBC, Case A) tumor when compared with a hormone-receptor-positive-Her2-negative (Non-TNBC, Case B) tumor specimen.
| Identified Proteins | Accession # | Cellular Function |
|---|---|---|
| 4-trimethylaminobutyraldehyde dehydrogenase (ALDH) | gi|62511242 | Catalyzes the irreversible oxidation of aldehydes to the corresponding acids in an NAD-dependent reaction. Stem cell marker |
| Annexin VI isoform 1 | gi|71773329 | Mediates the intracellular calcium Signal |
| ATP synthase, beta subunit precursor | gi|32189394 | ATP synthesis |
| Dipeptidyl peptidase III | gi|18491024 | Protease that is a member of the S9B family. Increased activity of this protein is associated with endometrial and ovarian cancers. |
| Elongation factor Tu, mitochondrial precursor (EF-Tu) | gi|1706611 | Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein synthesis. |
| Enolase 1 | gi|4503571 | Myc promoter-binding protein |
| Eukaryotic translation elongation factor 2 | gi|4503483 | Essential factor for protein synthesis |
| Heat shock 70kDa protein 5 | gi|16507237 | Cellular stress response |
| Heat shock 70kDa protein 8 isoform 1 | gi|5729877 | Cellular stress response |
| L-plastin | gi|4504965 | Actin-binding proteins expressed only in hemopoietic cell lineages in benigh tissue, but in malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. |
| Macrophage Migration Inhibitory Factor (Mif) | gi|13399777 | Inhibits macrophage migration and causes adherence |
| Mutated melanoma-associated antigen 1 | gi|152032608 | Melanoma-associated antigen |
| Proteasome (prosome, macropain) subunit, alpha type 6 | gi|8394076 | Central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus |
| Proteasome subunit, α5 | gi|7106387 | Protein degradation |
| Protein disulfide isomerase-associated 3 precursor | gi|21361657 | Endoplasmic reticulum protein interacting with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins |
| Protein disulfide isomerase-associated 4 | gi|4758304 | Catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the endoplasmic reticulum |
| Pyruvate kinase 3 isoform 1 | gi|33286418 (+2) | Catalyzes the rate-limiting step of glycolysis |
| Thioredoxin peroxidase | gi|5453549 | Antioxidant enzyme belongs to the peroxiredoxin family. Reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol. Regulate the activation of the transcription factor NF-kappaB |
| Tumor rejection antigen (gp96) 1 | gi|4507677 | Cellular stress response |
| Vesicle amine transport protein 1 | gi|18379349 | An abundant integral membrane protein involved in vesicular transport |