Table 1.
Associations of NR4A1 SNPs rs744690, rs2603751, and rs2242107 with metabolic parameters (n = 1495).
| SNP | rs744690 | rs2603751 | rs2242107 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | TT | TG | GG | Padd. | Pdom. | AA | AG | GG | Padd. | Pdom. | CC | CT | TT | Padd. | Pdom. |
| N | 1066 | 384 | 39 | - | - | 1156 | 313 | 20 | - | - | 769 | 589 | 131 | - | - |
| BMI (kg/m2) | 28.4 ± 8.1 | 28.4 ± 7.5 | 28.3 ± 7.4 | 0.8 | 0.6 | 28.5 ± 7.9 | 28.8 ± 8.2 | 29.6 ± 11.1 | 0.8 | 0.5 | 28.6 ± 7.9 | 28.4 ± 7.9 | 29.2 ± 8.8 | 0.7 | 0.9 |
| Waist circumference (cm) | 93 ± 17 | 94 ± 17 | 92 ± 15 | 0.7 | 0.9 | 94 ± 17 | 94 ± 18 | 91 ± 20 | 0.9 | 0.9 | 94 ± 17 | 93 ± 17 | 95 ± 18 | 0.4 | 0.4 |
| Glucose, fasting (mM) | 5.09 ± 0.55 | 5.10 ± 0.55 | 5.15 ± 0.54 | 0.8 | 0.5 | 5.10 ± 0.55 | 5.07 ± 0.54 | 4.96 ± 0.53 | 0.3 | 0.2 | 5.11 ± 0.56 | 5.07 ± 0.54 | 5.12 ± 0.53 | 0.7 | 0.4 |
| Glucose, 120 min. OGTT (mM) | 6.28 ± 1.65 | 6.11 ± 1.67 | 6.47 ± 1.73 | 0.14 | 0.08 | 6.24 ± 1.67 | 6.25 ± 1.63 | 6.09 ± 1.46 | 0.9 | 1.0 | 6.29 ± 1.68 | 6.17 ± 1.62 | 6.25 ± 1.68 | 0.4 | 0.15 |
| HOMA-IR (U) | 2.44 ± 2.11 | 2.36 ± 2.20 | 2.47 ± 2.73 | 0.8 | 1.0 | 2.42 ± 2.16 | 2.40 ± 2.12 | 2.78 ± 2.33 | 0.5 | 0.4 | 2.49 ± 2.13 | 2.28 ± 2.07 | 2.65 ± 2.57 | 0.06 | 0.06 |
| ISI, OGTT (U) | 16.7 ± 11.1 | 16.6 ± 10.3 | 15.4 ± 7.7 | 0.9 | 0.7 | 16.6 ± 10.9 | 16.6 ± 10.7 | 15.4 ± 11.1 | 0.7 | 0.7 | 16.4 ± 11.0 | 17.1 ± 10.8 | 15.7 ± 9.8 | 0.13 | 0.08 |
| ISI, clamp (U)# | 0.086 ± 0.053 | 0.086 ± 0.061 | 0.081 ± 0.040 | 0.9 | 0.6 | 0.086 ± 0.054 | 0.088 ± 0.058 | 0.046 ± 0.013 | 0.3 | 0.4 | 0.086 ± 0.054 | 0.085 ± 0.054 | 0.085 ± 0.064 | 0.7 | 0.8 |
| AUC Ins [30 min.]/AUC glc [30 min.] (pM/mM) | 40.5 ± 29.7 | 40.8 ± 32.0 | 35.2 ± 18.2 | 0.6 | 0.5 | 40.4 ± 29.1 | 40.0 ± 33.4 | 47.5 ± 29.4 | 0.2 | 0.3 | 41.0 ± 30.2 | 38.8 ± 27.5 | 44.1 ± 39.0 | 0.8 | 0.9 |
| AUC C-pep/AUC glc (pM/mM) | 317 ± 104 | 324 ± 117 | 304 ± 82 | 0.7 | 0.5 | 317 ± 106 | 324 ± 111 | 325 ± 111 | 0.6 | 0.3 | 318 ± 105 | 317 ± 106 | 331 ± 121 | 0.5 | 0.4 |
| Insulinogenic index (pM/mM) | 50.5 ± 40.5 | 51.8 ± 43.5 | 42.2 ± 22.8 | 0.7 | 0.4 | 50.6 ± 39.7 | 49.9 ± 45.4 | 58.6 ± 36.0 | 0.4 | 0.5 | 51.2 ± 41.4 | 48.7 ± 37.1 | 55.7 ± 52.6 | 0.6 | 0.8 |
Raw data are presented and given as means ± SD. For statistical analysis, data were loge-transformed. AUC Insulin [30 min.]/AUC glc [30 min.], AUC C-pep/AUC glc, and insulinogenic index were adjusted for gender, age, BMI, and ISI-OGTT. Fasting glucose, glucose at 120 min. of the OGTT, HOMA-IR, ISI-OGTT, and ISI-clamp were adjusted for gender, age, and BMI. BMI and waist circumference were adjusted for gender and age. AUC - area under the curve; BMI - body mass index; C-pep - C-peptide; glc - glucose; HOMA-IR - homeostasis model assessment of insulin resistance; ISI - insulin sensitivity index; OGTT - oral glucose tolerance test; p>add. - p-value in the addidtive inheritance model; pdom. - p-value in the dominant inheritance model; SNP - single nucleotide polymorphism; U - units. #N = 506.
Insulinogenic index was assessed as the ratio of (insulin at 30 min. of the OGTT - fasting insulin) to glucose at 30 min. of the OGTT.