Table 2.
Associations of NR4A1 SNPs rs2701124 and rs1283155 with metabolic parameters (n = 1495).
| SNP | rs2701124 | rs1283155 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | CC | CT | TT | Padd. | Pdom. | CC | CT | TT | Padd. | Pdom. |
| N | 1242 | 239 | 8 | - | - | 885 | 507 | 83 | - | - |
| BMI (kg/m2) | 28.5 ± 7.8 | 29.0 ± 8.6 | 32.3 ± 16.1 | 0.5 | 0.3 | 28.7 ± 8.2 | 28.5 ± 7.7 | 28.3 ± 7.7 | 0.8 | 0.6 |
| Waist circumference (cm) | 94 ± 17 | 93 ± 19 | 93 ± 28 | 1.0 | 0.8 | 94 ± 18 | 94 ± 17 | 93 ± 16 | 0.9 | 0.8 |
| Glucose, fasting (mM) | 5.10 ± 0.55 | 5.06 ± 0.54 | 5.11 ± 0.64 | 0.6 | 0.3 | 5.10 ± 0.55 | 5.10 ± 0.56 | 5.04 ± 0.48 | 0.4 | 0.7 |
| Glucose, 120 min. OGTT (mM) | 6.25 ± 1.66 | 6.22 ± 1.64 | 5.94 ± 1.75 | 0.7 | 0.7 | 6.32 ± 1.67 | 6.07 ± 1.62 | 6.46 ± 1.66 | 0.0078 | 0.0153 |
| HOMA-IR (U) | 2.41 ± 2.11 | 2.47 ± 2.35 | 2.68 ± 1.82 | 0.5 | 0.2 | 2.51 ± 2.30 | 2.31 ± 1.87 | 2.25 ± 2.28 | 0.3 | 0.17 |
| ISI, OGTT (U) | 16.6 ± 10.9 | 16.7 ± 10.5 | 16.1 ± 13.2 | 0.7 | 0.4 | 16.3 ± 10.7 | 16.9 ± 10.9 | 17.1 ± 10.9 | 0.2 | 0.08 |
| ISI, clamp (U)# | 0.086 ± 0.054 | 0.087 ± 0.058 | 0.054 ± 0.001 | 0.8 | 0.5 | 0.084 ± 0.052 | 0.089 ± 0.061 | 0.090 ± 0.046 | 0.7 | 0.9 |
| AUC Insulin [30 min.]/AUC glc [30 min.] (pM/mM) | 40.2 ± 29.0 | 41.4 ± 35.5 | 44.9 ± 23.8 | 0.9 | 0.6 | 41.3 ± 30.8 | 39.7 ± 28.4 | 37.8 ± 34.0 | 0.7 | 0.8 |
| AUC C-pep/AUC glc (pM/mM) | 317 ± 106 | 329 ± 113 | 312 ± 72 | 0.2 | 0.10 | 320 ± 103 | 320 ± 113 | 304 ± 108 | 0.6 | 0.9 |
| Insulinogenic index (pM/mM) | 50.3 ± 39.4 | 52.1 ± 48.4 | 56.1 ± 32.8 | 0.9 | 0.7 | 51.5 ± 41.7 | 50.0 ± 39.3 | 46.7 ± 44.6 | 0.8 | 0.6 |
Raw data are presented and given as means ± SD. For statistical analysis, data were loge-transformed. AUC Insulin [30 min.]/AUC glc [30 min.], AUC C-pep/AUC glc, and insulinogenic index were adjusted for gender, age, BMI, and ISI-OGTT. Fasting glucose, glucose at 120 min. of the OGTT, HOMA-IR, ISI-OGTT, and ISI-clamp were adjusted for gender, age, and BMI. BMI and waist circumference were adjusted for gender and age. AUC - area under the curve; BMI - body mass index; C-pep - C-peptide; glc - glucose; HOMA-IR - homeostasis model assessment of insulin resistance; ISI - insulin sensitivity index; OGTT - oral glucose tolerance test; padd. - p-value in the addidtive inheritance model; pdom. - p-value in the dominant inheritance model; SNP - single nucleotide polymorphism; U - units. # ISI (clamp) data were available from 506 subjects.
Insulinogenic index was assessed as the ratio of (insulin at 30 min. of the OGTT - fasting insulin) to glucose at 30 min. of the OGTT.