Table 2.
Quantitative association results for the candidate loci in the European American height cohort (n = 8,184), sorted by chromosomal location.
| Chr | Minor Allele | SNP | Position (Build 36) | Nearby genes(s) | NMISS | MAF | BETA | SE | R2 | T | P |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | A | rs11809207 | 26205282 | CATSPER4 | 8106 | 0.1730 | 0.02775 | 0.0213 | 0.0002095 | 1.303 | 0.1926 |
| 1 | C | rs6663565 | 41232781 | SCMH1 | 8184 | 0.4297 | 0.03744 | 0.01587 | 0.0006802 | 2.36 | 0.0183 |
| 1 | C | rs17038164 | 118574711 | SPAG17 | 8182 | 0.2601 | -0.06029 | 0.01784 | 0.001395 | -3.38 | 0.0007274 |
| 1 | G | rs11205277 | 146705945 | Histone class 2A, MTMR11, SV2A, SF3B4 | 8182 | 0.4195 | 0.0109 | 0.01579 | 5.83E-05 | 0.6906 | 0.4898 |
| 1 | G | rs678962 | 168921546 | DNM3 | 8178 | 0.2183 | 0.01272 | 0.0192 | 5.37E-05 | 0.6625 | 0.5077 |
| 1 | A | rs2274432 | 180752602 | C1orf19, GLT25D2 | 7965 | 0.3237 | 0.04568 | 0.01722 | 0.0008828 | 2.653 | 0.008003 |
| 1 | A | rs3942992 | 224079131 | ZNF678 | 8181 | 0.1725 | 9.96E-05 | 0.02072 | 2.83E-09 | 0.004809 | 0.9962 |
| 2 | G | rs3791679 | 56008543 | EFEMP1, PNPT1 | 8179 | 0.2539 | -0.0782 | 0.01798 | 0.002308 | -4.349 | 1.39×10-5 |
| 2 | T | rs1052483 | 219759853 | IHH, CRYBA2, FEV, SLC23A3, TUBA1 | 8110 | 0.0956 | -0.04701 | 0.02686 | 0.0003777 | -1.75 | 0.08009 |
| 3 | C | rs9841212 | 135674636 | ANAPC13, CEP63 | 8154 | 0.3289 | -0.006868 | 0.01676 | 2.06E-05 | -0.4098 | 0.682 |
| 3 | A | rs6763931 | 142585531 | ZBTB38 | 8174 | 0.4091 | 0.04634 | 0.01587 | 0.001042 | 2.92 | 0.003513 |
| 4 | T | rs6842303 | 17530324 | LCORL, NCAPG | 8173 | 0.2466 | 0.02231 | 0.01823 | 0.0001834 | 1.224 | 0.2209 |
| 4 | C | rs6830062 | 17693999 | LCORL, NCAPG | 8184 | 0.1883 | -0.05215 | 0.02014 | 0.0008192 | -2.59 | 0.009613 |
| 4 | A | rs1812175 | 145932449 | HHIP | 8172 | 0.1639 | -0.03329 | 0.02125 | 0.0003002 | -1.566 | 0.1173 |
| 5 | T | rs10472828 | 32924575 | NPR3 | 8182 | 0.4585 | -0.005366 | 0.01589 | 1.39E-05 | -0.3376 | 0.7357 |
| 6 | A | rs12198986 | 7665058 | BMP6 | 8183 | 0.4516 | -0.0003072 | 0.01598 | 4.52E-08 | -0.01922 | 0.9847 |
| 6 | G | rs10946808 | 26341366 | Histone class 1, Butyrophilin genes | 8164 | 0.2923 | -0.05734 | 0.01736 | 0.001336 | -3.304 | 0.0009572 |
| 6 | C | rs2844479 | 31680935 | HLA class III | 8183 | 0.3890 | -0.03031 | 0.01605 | 0.0004355 | -1.888 | 0.05907 |
| 6 | G | rs3130050 | 31726740 | HLA class III | 8178 | 0.1249 | 0.06717 | 0.02369 | 0.0009819 | 2.835 | 0.004598 |
| 6 | T | rs185819 | 32158045 | HLA class III | 8178 | 0.4576 | 0.0516 | 0.01576 | 0.001309 | 3.274 | 0.001066 |
| 6 | G | rs1776897 | 34302989 | HMGA1, LBH | 8183 | 0.0940 | 0.02524 | 0.02701 | 0.0001068 | 0.9348 | 0.3499 |
| 6 | A | rs2814993 | 34726871 | C6orf106 | 8091 | 0.1390 | 0.06941 | 0.02284 | 0.001141 | 3.039 | 0.002378 |
| 6 | A | rs4713858 | 35510763 | ANKS1, TCP11, ZNF76, DEF6, SCUBE3 | 8184 | 0.1730 | -0.02058 | 0.02103 | 0.000117 | -0.9786 | 0.3278 |
| 6 | C | rs314263 | 105499438 | LIN28B, HACE1, BVES, POPDC3 | 8184 | 0.3129 | 0.02821 | 0.01698 | 0.0003373 | 1.661 | 0.09665 |
| 6 | T | rs1490388 | 126877348 | C6orf173/LOC387103 | 8179 | 0.4784 | 0.05315 | 0.01571 | 0.001398 | 3.383 | 0.0007196 |
| 6 | G | rs3748069 | 142809326 | GPR126 | 8184 | 0.3126 | -0.06047 | 0.01695 | 0.001552 | -3.566 | 0.0003641 |
| 7 | T | rs798544 | 2536343 | GNA12 | 8184 | 0.2897 | 0.009501 | 0.01746 | 3.62E-05 | 0.5441 | 0.5864 |
| 7 | C | rs1182188 | 2643226 | GNA12 | 8184 | 0.2948 | 0.01528 | 0.01742 | 9.40E-05 | 0.8769 | 0.3806 |
| 7 | A | rs849141 | 27958331 | JAZF1 | 8180 | 0.2729 | 0.05199 | 0.01769 | 0.001055 | 2.939 | 0.0033 |
| 7 | C | rs2282978 | 91909061 | CDK6, PEX1, GATAD1, ERVWE1 | 8180 | 0.3562 | -0.0002285 | 0.01639 | 2.38E-08 | -0.01394 | 0.9889 |
| 7 | C | rs11765954 | 91925346 | CDK6, PEX1, GATAD1, ERVWE1 | 8183 | 0.2866 | 0.006002 | 0.01744 | 1.45E-05 | 0.3441 | 0.7307 |
| 8 | C | rs10958476 | 57258362 | PLAG1, MOS, CHCHD7, RDHE2, RPS20, LYN, TGS1, PENK | 8158 | 0.2015 | 0.05689 | 0.01979 | 0.001012 | 2.874 | 0.004062 |
| 8 | C | rs7846385 | 78322734 | PXMP3, ZFHX4 | 8175 | 0.2753 | 0.004128 | 0.01761 | 6.72E-06 | 0.2344 | 0.8147 |
| 9 | G | rs4448343 | 95345925 | PTCH1 | 8182 | 0.3217 | -0.007508 | 0.01686 | 2.42E-05 | -0.4453 | 0.6561 |
| 9 | A | rs4743034 | 106711908 | ZNF462 | 8183 | 0.2250 | 0.01859 | 0.01872 | 0.0001206 | 0.9933 | 0.3206 |
| 12 | C | rs8756 | 64646019 | HMGA2 | 8175 | 0.4607 | 0.02308 | 0.01586 | 0.0002588 | 1.455 | 0.1458 |
| 12 | G | rs3825199 | 92479422 | SOCS2, MRPL42, CRADD, UBE2N | 8183 | 0.2088 | 0.02109 | 0.0194 | 0.0001445 | 1.087 | 0.2769 |
| 13 | C | rs1239947 | 50004556 | DLEU7 | 8183 | 0.3287 | 0.03243 | 0.01678 | 0.0004563 | 1.933 | 0.05333 |
| 14 | C | rs910316 | 74695795 | TMED10 | 8184 | 0.4863 | -0.02021 | 0.01577 | 0.0002006 | -1.281 | 0.2002 |
| 14 | C | rs7153027 | 91496975 | TRIP11, FBLN5, ATXN3, CPSF2 | 8149 | 0.4316 | -0.02966 | 0.0158 | 0.0004323 | -1.877 | 0.06054 |
| 15 | C | rs2554380 | 82106888 | ADAMTSL3, SH3GL3 | 8067 | 0.1991 | 0.01455 | 0.02029 | 6.38E-05 | 0.7171 | 0.4734 |
| 15 | T | rs11633371 | 87157836 | ACAN | 8184 | 0.4636 | 0.02862 | 0.01575 | 0.0004032 | 1.817 | 0.06929 |
| 15 | A | rs4533267 | 98603794 | ADAMTS17 | 8184 | 0.2933 | -0.001093 | 0.01737 | 4.84E-07 | -0.06294 | 0.9498 |
| 17 | A | rs3760318 | 26271841 | CRLF3, ATAD5, CENTA2, RNF135 | 8184 | 0.3821 | -0.03009 | 0.01627 | 0.0004178 | -1.849 | 0.06444 |
| 17 | A | rs4794665 | 52205328 | NOG, DGKE, TRIM25, COIL, RISK | 8183 | 0.4756 | 0.006489 | 0.01569 | 2.09E-05 | 0.4135 | 0.6792 |
| 17 | A | rs757608 | 56852059 | BCAS3, NACA2, TBX2, TBX4 | 8126 | 0.3322 | 0.02008 | 0.01676 | 0.0001767 | 1.198 | 0.2309 |
| 18 | G | rs4800148 | 18978326 | CABLES1, RBBP8, C18orf45 | 8183 | 0.2043 | -0.04987 | 0.01943 | 0.0008048 | -2.567 | 0.01028 |
| 18 | T | rs530550 | 45105636 | DYM | 8182 | 0.3572 | -0.01124 | 0.01631 | 5.81E-05 | -0.6892 | 0.4907 |
| 19 | G | rs12459350 | 2127586 | DOT1L | 8179 | 0.4744 | 0.02751 | 0.01579 | 0.0003711 | 1.742 | 0.08149 |
| 20 | A | rs967417 | 6568893 | BMP2 | 8184 | 0.4495 | -0.02479 | 0.01591 | 0.0002964 | -1.558 | 0.1194 |
| 20 | C | rs4911494 | 33435328 | UQCC, GDF5, CEP250, EIF6, MMP24 | 8182 | 0.3864 | 0.05107 | 0.01621 | 0.001212 | 3.151 | 0.001633 |
The SNPs in bold are those that survived correction for multiple testing.
NMISS: number of individuals tested; MAF: minor allele frequency; BETA: regression coefficient for the test SNP; SE: standard error of the regression coefficient; R2: r2 value in linear regression; T: test statistic; P: two-sided trend test P-value. The direction of effect is shown for the minor allele in each case.