Table 3.
Association between type 2 diabetes and 19 SNPs in the eight genes/loci
| Gene | SNP | No. | LDa D'(r2) | P value for HWEb | Allel Frequency | Additive model | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | Trend p value | Adjusted p value | ORc (95% CI)d | Adjusted p value | OR (95% CI) | Adjusted p value | OR (95% CI) | ||||
| TCF7L2 | rs6585205 (T) | 1 | 1 vs 2: 0.28 (0.0070) | 0.54 | 0.31 | 0.43 | 0.39 | 0.003 | 0.055 | 4.0 × 10-4 | 1.31 (1.13, 1.53) | 0.287 | 1.11 (0.92, 1.35) | |
| rs7903146 (T) | 2 | 1 vs 3: 0.72 (0.33) | 0.25 | 0.24 | 0.06 | 0.04 | 3.6 × 10-4 | 0.007 | 1.54 (1.19, 1.99) | 0.001 | 1.58 (1.25, 2.03) | 0.691 | 1.41 (0.40, 5.02) | |
| rs11196218 (A) | 3 | 2 vs 3: 0.28 (0.01) | 0.26 | 0.60 | 0.29 | 0.30 | 0.520 | 9.880 | ||||||
| HHEX | rs1111875 (G) | 4 | 5 vs 4: 0.39 (0.11) | 0.11 | 0.32 | 0.32 | 0.28 | 0.001 | 0.016 | 1.11 (0.97, 1.27) | 0.005 | 1.23 (1.07, 1.42) | 0.011 | 1.43 (1.08, 1.89) |
| rs7923837 (G) | 5 | 5 vs 6: 0.53 (0.18) | 0.24 | 0.99 | 0.30 | 0.25 | 1.4 × 10-5 | 2.7 × 10-4 | 1.08 (0.93, 1.25) | 8.6 × 10-6 | 1.39 (1.20, 1.61) | 0.062 | 1.30 (0.99, 1.72) | |
| rs5015480 (C) | 6 | 4 vs 6: 0.69 (0.21) | 0.69 | 0.41 | 0.21 | 0.17 | 0.001 | 0.027 | 1.20 (0.96, 1.54) | 3.3 × 10-4 | 1.32 (1.14, 1.54) | 0.657 | 1.08 (0.75, 1.59) | |
| CDKLA1 | rs736425 (C) | 7 | 8 vs 9: 0.55 (0.056) | 0.48 | 0.93 | 0.07 | 0.07 | 0.782 | 14.849 | |||||
| rs10946398 (C) | 8 | 7 vs 8: 0.11 (0.0011) | 0.79 | 0.36 | 0.45 | 0.37 | 1.2 × 10-9 | 2.2 × 10-8 | 1.36 (1.20, 1.55) | 2.7 × 10-6 | 1.44 (1.24, 1.68) | 6.3 × 10-9 | 1.78 (1.46, 2.17) | |
| rs4712527 (G) | 9 | 7 vs 9: 0.086 (0.0020) | 0.07 | 0.52 | 0.22 | 0.21 | 0.270 | 5.132 | ||||||
| SCL30A8 | rs13266634 (C) | 10 | 10 vs 11 0.99 (0.55) | 0.13 | 0.08 | 0.59 | 0.54 | 1.4 × 10-4 | 0.003 | 1.37 (1.20, 1.56) | 0.005 | 1.32 (1.09, 1.60) | 0.001 | 1.31 (1.11, 1.53) |
| rs3802177 (C) | 11 | 10 vs 12 0.95 (0.64) | 0.96 | 0.15 | 0.60 | 0.53 | 9.9 × 10-8 | 1.9 × 10-6 | 1.33 (1.18, 1.52) | 0.007 | 1.29 (1.07, 1.57) | 1.2 × 10-8 | 1.58 (1.35, 1.84) | |
| rs11558471 (A) | 12 | 11 vs 12 0.96 (0.67) | 0.96 | 0.86 | 0.58 | 0.52 | 3.5 × 10-6 | 6.6 × 10-5 | 1.25 (1.11, 1.41) | 1.7 × 10-4 | 1.41 (1.18, 1.69) | 1.5 × 10-4 | 1.35 (1.16, 1.59) | |
| PPARG | rs180282 (G) | 13 | 13 vs 14: 0.87 (0.079) | 0.30 | 0.78 | 0.06 | 0.05 | 0.394 | 7.482 | |||||
| rs12636454 (C) | 14 | 14 vs 15: 0.89 (0.38) | 0.95 | 0.81 | 0.32 | 0.33 | 0.523 | 9.928 | ||||||
| rs11128597 (A) | 15 | 13 vs 15: 0.70 (0.022) | 0.14 | 0.43 | 0.48 | 0.46 | 0.296 | 5.618 | ||||||
| IGF2BP2 | rs4402960 (T) | 16 | 0.46 | 0.53 | 0.23 | 0.22 | 0.176 | 3.335 | ||||||
| KCNJ11 | rs5215 (C) | 17 | 0.21 | 0.28 | 0.42 | 0.41 | 0.225 | 4.277 | ||||||
| CDKN2A/ | rs564398 (C) | 18 | 18 vs 19 0.12 (0.0011) | 0.00 | 0.27 | 0.01 | 0.01 | 0.627 | 11.913 | |||||
| CDKN2B | rs10811661 (C) | 19 | 0.26 | 0.56 | 0.05 | 0.05 | 0.880 | 1.670 | ||||||
a: Linkage disequilibrium (LD), b: Hardy-Weinberg equilibrium, c: Odds ratio (OR), d: Confidence interval (CI).