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. 2010 Jun 30;5(6):e11154. doi: 10.1371/journal.pone.0011154

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Kowarsch et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Signaling proteins are divided into four different cellular location groups (extracellular region, cell membrane, intracellular region, and nucleus) based on their NCI PID annotation. We calculated the enrichment of microRNA targets and disease proteins by a LOD score. We found an opposing patterns of cellular localization for disease-associated proteins and microRNA targets. B: Process type information obtained by the NCI PID database was used to divide signaling proteins into three different groups, activators, inhibitors, and ambivalent proteins (annotated as both activators and inhibitors). The result indicates again complementary patterns for microRNA targets and human disease proteins. * indicates significant enrichment obtained by Fisher's exact test ().

Inline graphic — A: Signaling proteins are divided into four different cellular location groups (extracellular region, cell membrane, intracellular region, and nucleus) based on their NCI PID annotation. We calculated the enrichment of microRNA targets and disease proteins by a LOD score. We found an opposing patterns of cellular localization for disease-associated proteins and microRNA targets. B: Process type information obtained by the NCI PID database was used to divide signaling proteins into three different groups, activators, inhibitors, and ambivalent proteins (annotated as both activators and inhibitors). The result indicates again complementary patterns for microRNA targets and human disease proteins. * indicates significant enrichment obtained by Fisher's exact test ().