Table 1. Core set of signaling pathways with highly enriched microRNA targets.

Pathway	Median LOD	microRNA	Z-score	Z-score
Rhodopsin	0.76	miR-154	8.69	6.58
Botulinum	0.61	miR-29b	8.58	8.10
TGFBR	0.61	miR-216a	12.20	7.10
BMP	0.60	miR-224	9.37	7.93
IGF1	0.59	miR-375	9.39	8.12
VEGFR3	0.57	miR-422a	8.29	7.89
EphrinB/EPHB	0.57	miR-422a	11.44	8.06
PDGFa	0.56	miR-383	7.20	7.59
MET	0.55	miR-422a	10.96	7.61
EphrinA/EPHA	0.53	miR-136	8.31	8.15
RET	0.52	miR-422a	9.04	7.24
VEGFR1	0.51	miR-422a	11.72	7.82
REELIN	0.51	miR-197	7.76	6.86
TRKR	0.49	miR-335	12.94	7.88
mTOR4	0.47	miR-375	7.23	7.44
EPO	0.43	miR-134	6.75	8.00

The Median LOD score is calculated over all diseases for a particular pathway. MicroRNA is the most enriched single microRNA within the corresponding pathway. Z-score was calculated by comparing the median LOD score with the obtained score by a random sampling of microRNA targets. Z-score was calculated by comparing the median LOD score with the obtained score by a random sampling of pathway proteins.