Table 1.

Wound healing rate constants and half times. FCS, foetal calf serum (10%); TGF-α, transforming growth factor-α (10 ng ml⁻¹); t_1/2, half time. Calculations of the rate constant and half time of wound healing of alveolar epithelial type II cells. The rate constant (k) for each condition was calculated by using a nonlinear least squares fitting equation (5 data points at 4, 6, 8, 10 and 12 h in vitro; every 40 min up to 12 h in silico) of % wound closure (W = 100(1 − e^kt)), where W is % wound closure and t is the time. The t_1/2 was derived from t_1/2 = ln 2/k.

conditions	rate constant (% h−1)	t1/2 (h)
in vitro
control (Kheradmand et al. 1994)	0.04	17.5
FCS (Kheradmand et al. 1994)	0.28	2.4
TGF-α (Kheradmand et al. 1994)	0.10	7.2
fibronectin (Garat et al. 1996)	0.14	4.9
in silico
random migration (0.4 grid unit per cycle)	0.019	36.48
random migration (1.0 grid unit per cycle)	0.030	22.79
random migration (1.6 grid unit per cycle)	0.043	16.08
random migration (2.0 grid unit per cycle)	0.049	14.05
factor-responsive (0.4 grid unit per cycle)	0.102	6.80
factor-responsive (1.0 grid unit per cycle)	0.261	2.66
factor-responsive (1.6 grid unit per cycle)	0.376	1.84
factor-responsive (2.0 grid unit per cycle)	0.436	1.59