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. 2010 Mar 24;7(50):1257–1274. doi: 10.1098/rsif.2010.0007

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© 2010 The Royal Society

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Figure 1. — Observed dynamics of influenza A (H3N2) in humans. (a) The case dynamics of influenza in France over the period 1984–2008 are shown in black (http://www.sentiweb.org/). Starting in 1997, FluNet data were available to estimate variant-specific dynamics (http://gamapserver.who.int/GlobalAtlas/). The subset of cases attributed to influenza A (H3N2) is shown in red after this date. (b) The annual attack rate of influenza in France, computed from the case dynamics shown in (a). Starting in 1997, the attack rate is partitioned into H3N2 cases (red) and H1N1/B cases (grey). Case dynamics are shown for France owing to the availability of data. Similar case dynamics are observed in other temperate regions, with similar estimated attack rates. (c) The phylogeny of influenza A (H3N2)'s HA, inferred from antigenically typed sequences isolated between 1968 and 2003 (Smith et al. 2004). Sequences are coloured by antigenic cluster.