Figure 4.
Neuronal activity generated by potassium lateral diffusion in CA1 pyramidal neuronal network exposed to zero calcium solution. Schematic diagram of 16-compartment CA1 pyramidal neuronal network consisting of four neurons is shown in (a). The model neuron consists of five compartments for the basal dendrite, 10 compartments for the apical dendrite, and one compartment for the soma. Neuron-1 was excited by long pulse stimulation (40 s, 2 nA). With the volume ratio rv = 0.15 and the radius of soma R = 8.9 μm, the distance between the first and the last was estimated as 74.56 μm. The membrane potential of each neuron plotted in three different time-frames (b). While the neuron-1 was inactivated during the stimulation, neuron-2 started firing first, and then neuron-3 and finally neuron-4 fired consecutively showing propagation in time. Immediately following stimulation, neuron-1 was activated and the activity for all neurons lasted about 50 s. The bursting patterns observed in experiments and in simulations are compared and shown in (c). The spontaneous triplet bursting observed from experiments (see fig. 3A in Shuai et al. (2003)) is shown on the right and the bursting pattern obtained from the simulation is shown on the left. (Modified from Park & Durand 2006)