Figure 5. Cold-induced UCP1 expression is attenuated in iWAT in COX2 KO mice.

A B COX2 KO mice and wild-type littermates were warm-acclimated at 28–30°C for 10 days and then transferred to 4–6°C for 48 h. Rectal temperature was measured before transfer and after 24 and 48 h (A). RNA was extracted and expressions of genes were measured by RT-qPCR (B). The bars represent mean ± standard error (n = 5–6). * indicates statistical significant difference between wild-type and KO mice (p<0.05).