Figure 1. Peptoid combinatorial libraries as sources of structures that antagonize protein-protein interactions.

(A) General structure of the combinatorial N-alkyl glycine library. (B) Yeast two-hybrid screening for peptoid pools that inhibit the Ubc13-Uev1 interaction. As a control interaction, the p53-large T interaction was assayed with the same pools in parallel assays. The β-galactosidase activity was normalized to the values for the control interaction, and to the values for the Ubc13-Uev1 interaction in the presence of solvent only (without peptoids). (C) Structures of the individual peptoids inferred as the most likely active inhibitors of the Ubc13-Uev1 interaction.