Table 2. Model base case clinical values and ranges used for sensitivity analyses.
Variable | Base Case (range) | Source | |
Clinical values | Baseline CD4+ countsa | 750 (600–1200) | [1], [17] |
Annual CD4+ count declinea | 60 (37–77) | [17] | |
Annual CD4 count increasea | 100 (60–120) | [18] | |
Epidemiological values | Syphilis incidenceb | 7.75 (3.6–11) | [13] |
Gonorrhea incidenceb | 8 (3.8–12.19) | [13] | |
Chlamydia incidenceb | 10.5 (5.51–15) | [13] | |
HIV incidenceb | 2.01 (1–3) | [13] | |
Mujer Segura effectivenessc | 40% (20–60%) | [13], [23], [24] | |
Probability of leaving sex workb | 21.5 (10–35) | [20] | |
Background mortality | Life tables | [22] | |
HIV/AIDS medical costs (annual) | CD4+ cell counts: | ||
More than 350 | $3,745d | [3], [25] | |
Between 200–349 | $4,186d | [3], [25] | |
Between 100–199 | $4,287d | [3], [25] | |
Less than 100 | $5,305d | [3], [25] | |
Annual probability of initiating HAART e | CD4+ cell counts: | ||
More than 350 | 9%d | [3], [19] | |
Between 200–349 | 40%d | [3], [19] | |
Between 100–199 | 49%d | [3], [19] | |
Less than 100 | 6%d | [3], [19] |
cells per microliter.
Per 100 person years.
Risk reduction for sexually transmitted infections among female sex workers.
Probability distribution used for probabilistic sensitivity analysis.
Highly Active Antiretroviral Therapy.