Table 3.
Frequency distribution of CFTR genotypes among cases and controls and their association with lung cancer risk: A Mayo Clinic case-control study of lung cancer, 1998–2007
| Mutations | Cases N(%) |
Controls N(%) |
Logistic regressiona |
||
|---|---|---|---|---|---|
| OR(95%CI) | p | Trend pb | |||
| ΔF508 deletion: rs332 | 0.010 | ||||
| Non-carriers | 535(98.3) | 603(94.5) | 1.00(Reference) | ||
| Carriers | 9(1.7) | 35(5.5) | 0.37(0.17–0.78) | 0.010 | |
| SNP1: rs17139943 | 0.800 | ||||
| AA | 347(60.6) | 413(60.8) | 1.00(Reference) | ||
| GA | 211(36.8) | 226(33.3) | 1.18(0.90–1.56) | 0.227 | |
| GG | 15(2.6) | 40(5.9) | 0.49(0.24–1.01) | 0.052 | |
| GA+GG | 226(39.4) | 266(39.2) | 1.08(0.83–1.41) | 0.557 | |
| SNP2: rs17449197 | 0.961 | ||||
| AA | 431(75.2) | 515(76.0) | 1.00(Reference) | ||
| GA | 136(23.7) | 149(22.0) | 1.02(0.75–1.40) | 0.892 | |
| GG | 6(1.1) | 14(2.0) | 0.57(0.17–1.88) | 0.356 | |
| GA+GG | 142(24.8) | 163(24.0) | 0.99(0.73–1.35) | 0.951 | |
| SNP3: rs213950 | 0.019 | ||||
| GG | 204(35.7) | 227(33.4) | 1.00(Reference) | ||
| GA | 292(51.1) | 323(47.6) | 0.54(0.36–0.80) | 0.001 | |
| AA | 76(13.3) | 129(19.0) | 0.58(0.39–0.88) | 0.004 | |
| GA+AA | 368(64.4) | 452(66.6) | 0.55(0.38–0.81) | 0.002 | |
| SNP4: rs10487372 | 0.003 | ||||
| CC | 459(80.4) | 500(74.5) | 1.00(Reference) | ||
| TC | 108(18.9) | 160(23.9) | 0.62(0.44–0.86) | 0.004 | |
| TT | 4(0.7) | 11(1.6) | 0.70(0.21–2.33) | 0.556 | |
| TC+TT | 112(19.6) | 171(25.5) | 0.63(0.45–0.87) | 0.005 | |
| SNP5: rs1469486 | 0.203 | ||||
| CC | 463(80.7) | 550(81.1) | 1.00(Reference) | ||
| TC | 108(18.8) | 125(18.4) | 0.89(0.63–1.25) | 0.948 | |
| TT | 3(0.5) | 3(0.4) | 0.56(0.07–4.79) | 0.853 | |
| TC+TT | 111(19.3) | 128(18.8) | 0.89(0.63–1.25) | 0.495 | |
| SNP6: rs17547853 | 0.669 | ||||
| GG | 404(70.6) | 476(70.1) | 1.00(Reference) | ||
| GA | 161(28.2) | 179(26.4) | 2.63(0.95–7.26) | 0.062 | |
| AA | 7(1.2) | 24(3.5) | 2.44(0.90–6.59) | 0.079 | |
| GA+AA | 168(29.4) | 203(29.9) | 2.61(0.99–6.89) | 0.053 | |
| SNP7: rs213968 | 0.056 | ||||
| CC | 207(36.1) | 228(33.6) | 1.00(Reference) | ||
| TC | 289(50.4) | 323(47.7) | 1.20(0.76–1.36) | 0.991 | |
| TT | 77(13.4) | 127(18.7) | 0.57(0.38–1.86) | 0.063 | |
| TC+TT | 366(63.8) | 450(66.4) | 0.89(0.68–1.17) | 0.404 | |
| SNP8: rs11978434 | 0.798 | ||||
| TT | 327(57.0) | 389(58.3) | 1.00(Reference) | ||
| TC | 228(39.7) | 233(34.9) | 1.95(0.99–3.83) | 0.059 | |
| CC | 19(3.3) | 45(6.8) | 1.60(0.89–3.33) | 0.068 | |
| TC+CC | 247(43.0 | 278(41.7) | 1.72(0.92–3.21) | 0.088 | |
| SNP9: rs213988 | 0.696 | ||||
| CC | 362(63.3) | 431(63.8) | 1.00(Reference) | ||
| TC | 196(34.3) | 214(31.6) | 1.17(0.89–1.55) | 0.163 | |
| TT | 14(2.4) | 31(4.6) | 0.59(0.27–1.32) | 0.198 | |
| TC+TT | 210(36.7) | 245(36.2) | 1.07(0.84–1.36) | 0.471 | |
Bold characters indicate corresponding p values that are less than 0.05.
a
ORs and p values were adjusted for gender, age, cigarette smoking, SHS, COPD, and family history of lung cancer.
b
P values were adjusted for gender, age, cigarette smoking, SHS, COPD, and family history of lung cancer with the genotypes as values of 0, 1, and 2 in one model.