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. 2010 Jun 2;107(25):11307–11312. doi: 10.1073/pnas.1000806107

Fig. 3.

Fig. 3.

The PDGF-B:PDGFRβ interface. (A) An overview of the composite interface. The structural segments involved in binding are shown as thicker coils than the nonbinding segments, with the protruding PDGF-B protomer in cyan, the receding PDGF-B protomer in green, and PDGFRβ in pink. (B) Stereo view of the receptor-ligand interface in the same orientation, with main chains shown as coils and side chains shown as sticks. Note that upper patch and the lower patch of the interface are related by ∼110°. (C) The role of PDGF-B residues Arg27 and Ile30 (highlighted in green) in maintaining the receptor-binding conformation of the L1 loop. The view is rotated ∼70° from B.