Table 1.
Description of the pockets detected in conformation 1 of the EF transition path
| Pocket number | Volume ( ) |
Number of residues | Number of counterparts in CyaA | |||
| Total | Conserved | Similar profile | Similar shape only | |||
| 1 (catalytic) | 871 | 23 | 23 | 17 | 2 | 1 |
| 2 (SABC) | 463 | 16 | 15 | 6 | 3 | 2 |
| 3 | 227 | 12 | 8 | 1 | 1 | 0 |
| 4 | 188 | 10 | 4 | 2 | 0 | 0 |
| 5 (SBC) | 171 | 9 | 8 | 6 | 0 | 0 |
| 6 | 160 | 12 | 12 | 1 | 0 | 1 |
| 7 | 156 | 11 | 11 | 1 | 1 | 1 |
| 8 | 129 | 9 | 3 | 0 | 0 | 0 |
| 9 | 123 | 10 | 0 | 0 | 0 | 0 |
| 10 | 110 | 8 | 8 | 3 | 0 | 0 |
| 11 | 104 | 11 | 9 | 1 | 0 | 0 |
Similar profiles correspond to residues belonging to the same physicochemical family, whereas similar shapes correspond to residues with the same steric hindrance.