Skip to main content
. 2010 Jun 4;107(25):11585–11590. doi: 10.1073/pnas.1003287107

Fig. 2.

Fig. 2.

ART promotes topographically specific regeneration of myelinated cutaneous afferents in the dorsal horn. (A–E) Central projections of cutaneous sensory afferents visualized by small intradermal injections of CTB into the C6 dermatome. (A) Projections in a control cord. (B) Regenerated projections in an sNgR-treated cord after 4 wk. (C–E) Regenerated projections in ART-treated cords after 2 wk (C), 3 wk (D), and 4 wk (E). (F) Time course of appearance of synaptic puncta from regenerated cutaneous sensory axons in ART-treated cords. Asterisks denote significant differences from those of 4-wk untreated cords or after 1 wk of ART treatment (P < 0.001). (G and H) Artemin promotes regeneration of cutaneous sensory afferents to topographically correct regions of the dorsal horn. The areas in the dorsal horn occupied by CTB-labeled puncta are shown in different colors for nine ART-treated animals. Colors are matched for each animal on the control and regenerated sides. See Materials and Methods for details of the analysis. Images in control panels (uncrushed axons) have been reversed horizontally in A and G to facilitate comparison with projections of regenerated axons.