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Screening of avermectin B1a overproduction mutants transformed with optimal mutant hrdB gene. S. avermitilis 3-115 was used as the control (dashed line -100%), and the error bars represent standard deviations. All samples were cultured in Erlenmeyer flasks and measured in triplicate. C1: strain containing a blank pSET152; C2: strain containing an additional copy of wild-type hrdB gene.
