Table 2.

Group means and differences between schizophrenia patients and combined controls (mood disorder and healthy controls) for grey and white matter volumes

	Group; brain volume, mm3, mean* (SE)				Schizophrenia v. mood disorder and healthy control participants
Brain region	Schizophrenia, n = 12	Mood disorder, n = 12	Healthy control, n = 17	Mood + control, n = 29	Difference	SE	%	p value
Intracranial	1303.0 (37.0)	1273.7 (37.9)	1360.9 (30.3)	1317.3 (23.9)	−14.4	25.4	−1.1	0.75
Cerebrospinal fluid	223.5 (4.5)	197.9 (4.8)	199.0 (3.8)	198.7 (3.1)	25.0	5.4	12.6	< 0.001
Lateral ventricle	13.3 (1.1)	13.4 (1.2)	11.2 (1.0)	12.3 (0.7)	1.0	1.4	8.1	0.46
Total grey and white matter	1094.5 (5.6)	1116.4 (4.4)	1118.6 (2.6)	1116.4 (2.5)	−23.0	6.2	−2.1	< 0.001
Frontal lobe	554.5 (4.0)	564.4 (3.1)	571.0 (3.1)	567.1 (2.2)	−13.2	4.7	−2.3	0.008
Occipital lobe	146.9 (2.6)	150.3 (2.2)	148.6 (2.5)	149.3 (1.7)	−2.5	3.2	−1.7	0.44
Parietal lobe	204.4 (1.9)	212.1 (2.4)	208.6 (1.9)	210.1 (1.5)	−5.9	2.5	−2.8	0.024
Temporal lobe	188.6 (3.4)	189.5 (2.3)	190.5 (2.1)	189.8 (1.5)	−1.3	4.0	−0.7	0.74
Grey matter	647.4 (7.6)	676.6 (5.3)	674.7 (2.9)	675.0 (2.8)	−28.3	8.3	−4.2	0.002
Frontal lobe	292.1 (4.2)	306.6 (3.1)	308.2 (1.9)	307.1 (1.7)	−15.3	4.7	−5.0	0.002
Occipital lobe	113.3 (2.2)	117.2 (1.7)	116.5 (1.9)	116.7 (1.3)	−3.6	2.6	−3.1	0.18
Parietal lobe	117.4 (2.1)	126.7 (1.5)	123.4 (1.4)	124.9 (1.0)	−7.7	2.4	−6.2	0.003
Temporal lobe	124.6 (2.4)	126.1 (1.9)	126.6 (1.5)	126.2 (1.1)	−1.7	2.8	−1.4	0.55
White matter	447.1 (4.1)	439.8 (3.9)	444.0 (2.1)	441.4 (2.1)	5.3	4.7	1.2	0.27
Frontal lobe	262.4 (3.3)	257.7 (2.6)	262.9 (2.1)	260.0 (1.6)	2.1	3.7	0.8	0.58
Occipital lobe	33.7 (0.9)	33.2 (0.9)	32.1 (1.0)	32.6 (0.7)	1.0	1.2	3.2	0.37
Parietal lobe	87.0 (1.2)	85.4 (1.3)	85.1 (0.8)	85.2 (0.7)	1.7	1.4	2.0	0.24
Temporal lobe	64.1 (1.3)	63.4 (1.4)	63.9 (0.9)	63.6 (0.8)	0.4	1.6	0.6	0.82

SE = standard error of the mean.

^*Adjusted for age and intracranial volume.