Table 2.
Group; brain volume, mm3, mean* (SE) |
Schizophrenia v. mood disorder and healthy control participants |
|||||||
---|---|---|---|---|---|---|---|---|
Brain region | Schizophrenia, n = 12 | Mood disorder, n = 12 | Healthy control, n = 17 | Mood + control, n = 29 | Difference | SE | % | p value |
Intracranial | 1303.0 (37.0) | 1273.7 (37.9) | 1360.9 (30.3) | 1317.3 (23.9) | −14.4 | 25.4 | −1.1 | 0.75 |
Cerebrospinal fluid | 223.5 (4.5) | 197.9 (4.8) | 199.0 (3.8) | 198.7 (3.1) | 25.0 | 5.4 | 12.6 | < 0.001 |
Lateral ventricle | 13.3 (1.1) | 13.4 (1.2) | 11.2 (1.0) | 12.3 (0.7) | 1.0 | 1.4 | 8.1 | 0.46 |
Total grey and white matter | 1094.5 (5.6) | 1116.4 (4.4) | 1118.6 (2.6) | 1116.4 (2.5) | −23.0 | 6.2 | −2.1 | < 0.001 |
Frontal lobe | 554.5 (4.0) | 564.4 (3.1) | 571.0 (3.1) | 567.1 (2.2) | −13.2 | 4.7 | −2.3 | 0.008 |
Occipital lobe | 146.9 (2.6) | 150.3 (2.2) | 148.6 (2.5) | 149.3 (1.7) | −2.5 | 3.2 | −1.7 | 0.44 |
Parietal lobe | 204.4 (1.9) | 212.1 (2.4) | 208.6 (1.9) | 210.1 (1.5) | −5.9 | 2.5 | −2.8 | 0.024 |
Temporal lobe | 188.6 (3.4) | 189.5 (2.3) | 190.5 (2.1) | 189.8 (1.5) | −1.3 | 4.0 | −0.7 | 0.74 |
Grey matter | 647.4 (7.6) | 676.6 (5.3) | 674.7 (2.9) | 675.0 (2.8) | −28.3 | 8.3 | −4.2 | 0.002 |
Frontal lobe | 292.1 (4.2) | 306.6 (3.1) | 308.2 (1.9) | 307.1 (1.7) | −15.3 | 4.7 | −5.0 | 0.002 |
Occipital lobe | 113.3 (2.2) | 117.2 (1.7) | 116.5 (1.9) | 116.7 (1.3) | −3.6 | 2.6 | −3.1 | 0.18 |
Parietal lobe | 117.4 (2.1) | 126.7 (1.5) | 123.4 (1.4) | 124.9 (1.0) | −7.7 | 2.4 | −6.2 | 0.003 |
Temporal lobe | 124.6 (2.4) | 126.1 (1.9) | 126.6 (1.5) | 126.2 (1.1) | −1.7 | 2.8 | −1.4 | 0.55 |
White matter | 447.1 (4.1) | 439.8 (3.9) | 444.0 (2.1) | 441.4 (2.1) | 5.3 | 4.7 | 1.2 | 0.27 |
Frontal lobe | 262.4 (3.3) | 257.7 (2.6) | 262.9 (2.1) | 260.0 (1.6) | 2.1 | 3.7 | 0.8 | 0.58 |
Occipital lobe | 33.7 (0.9) | 33.2 (0.9) | 32.1 (1.0) | 32.6 (0.7) | 1.0 | 1.2 | 3.2 | 0.37 |
Parietal lobe | 87.0 (1.2) | 85.4 (1.3) | 85.1 (0.8) | 85.2 (0.7) | 1.7 | 1.4 | 2.0 | 0.24 |
Temporal lobe | 64.1 (1.3) | 63.4 (1.4) | 63.9 (0.9) | 63.6 (0.8) | 0.4 | 1.6 | 0.6 | 0.82 |
SE = standard error of the mean.
Adjusted for age and intracranial volume.