Table 4.

IC₅₀ Concentration of Antiviral Drugs in Different Cells against Four Different Drug-Sensitive HIV Isolates

		HIV-1 Strain
		Ba-L			NL4-3			208K10			208K8
		Cell type
Drug	Dose rangea(μM)	PHA-blasts	C8166-Rt	MT4-R5	PHA-blasts	C8166-Rt	MT4-R5	PHA-blasts	C8166-Rt	MT4-R5	PHA-blasts	C8166-Rt	MT4-R5
NRTI
AZT	0.08–10	<0.08b	2	NTc	<0.08	<0.08	<0.08	<0.08	<0.08	<0.08	>10	<0.08	NT
d4T	0.08–10	0.4	2	NT	0.4	0.08	0.08	0.08	0.08	0.08	0.08	0.4	2
ddI	0.08–10	10	10	NT	10	2	0.4	2	0.4	0.08	10	2	10
ddC	0.008–1	0.04	0.008	NT	0.2	0.2	0.2	0.008	0.04	0.008	0.2	0.2	0.2
3TC	0.04–5	0.2	0.04	NT	0.2	0.2	0.2	0.04	0.04	0.2	0.04	0.2	1
ABC	0.5–62.5	2.5	12.5	NT	12.5	62.5	NT	12.5	62.5	NT	12.5	2.5	NT
NNRTI
DLV	0.001–0.180	0.180	0.007	0.0070	0.001	0.007	0.04	0.007	0.007	0.001	0.007	0.001	0.001
EFV	0.003–0.317	0.0025	0.0025	0.0025	0.0025	0.0025	0.0025	0.0025	0.0025	0.0025	0.0025	0.0025	0.0127
NVP	0.003–0.376	0.015	0.376	0.3760	0.075	0.003	0.376	0.075	0.015	0.003	0.376	0.003	0.075
PI
IDV	0.001–0.140	0.140	0.028	NT	0.006	0.028	0.028	0.028	0.140	0.028	0.028	0.006	NT
NFV	0.001–0.15	0.03	0.03	NT	0.006	0.001	0.006	0.151	0.151	0.006	0.03	0.006	0.03
RTV	0.002–0.28	0.277	0.277	NT	0.011	0.011	0.277	0.277	0.055	0.055	0.055	0.055	0.055
SQV	0.001–0.13	0.026	0.026	0.0260	0.005	0.026	0.026	0.026	0.026	0.001	0.005	0.005	0.005
APV	0.001–0.16	0.001	0.03	0.007	0.007	0.03	0.007	0.007	0.007	0.007	0.03	0.03	0.03

^aDose range indicates the range of concentrations of antiviral drugs tested.

^bInhibitory drug concentration (IC₅₀) is defined as the lowest drug concentration tested giving 50% or greater inhibition of p24 production compared to drug-free control wells.

^cNT, not tested.