. Author manuscript; available in PMC: 2011 Jun 22.

Published in final edited form as: Biochemistry. 2010 Jun 22;49(24):5048–5056. doi: 10.1021/bi1005046

Table 5.

Average Metal Ion Coordination Distances (Å) in D101L HDAC8

Catalytic Metal Ion	D178	D267	H180	W1^b	W2^b	Hydroxamate (N–O, C=O)
Co²⁺	2.0	2.0	2.1	2.8	2.1	1.8, 2.4
Fe²⁺	1.9	2.0	2.1	2.1	2.2	1.9, 2.6
Mn²⁺	2.1	2.0	2.2	2.0	2.3	2.2, 2.4
Zn²⁺ ^a	2.0	2.0	2.1	2.3	2.1	2.5, 2.3

Reference (36).

W1 is the water molecule that is closest to the binding site of the hydroxamate OH group, and W2 is the water molecule that is closest to the binding site of the hydroxamate C=O group.