Tabel III.

Comparison of MUG^SR, FEATURE, and LIGSITE^CSC

			FEATURE
Criteriaa		MUGSR	SEL leveragedb to MUGSR	SEN leveraged to MUGSR	Score cutoff 50.0	LIGSITECSC
One	Hits	795	2270	5881	142	78
	Correct hits	417	1188	2174	123	9
	Predicted pockets	45	43	45	21	9
	Sensitivity	94%	88%	94%	43%	19%
	Selectivity	52%	52%	40%	87%	11%
Two	Hits	795	1386	4706	142	78
	Correct hits	341	599	1161	108	3
	Predicted pockets	44	33	44	21	3
	Sensitivity	90%	67%	90%	43%	6%
	Selectivity	43%	43%	25%	76%	4%
Three	Hits	795	1010	3282	142	78
	Correct hits	221	286	469	77	1
	Predicted pockets	38	29	38	20	1
	Sensitivity	78%	59%	78%	41%	2%
	Selectivity	28%	28%	13%	54%	1%

^aA hit is correct if it contains one (two, three) true ligand residues.

^bSEL of FEATURE is adjusted, by tuning the cutoff score, to be the same as that of MUG^SR.