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. 2010 Jul 7;99(1):227–237. doi: 10.1016/j.bpj.2010.03.071

Table 3.

Classification of amino acids by residue size

20 2 20 2 20 2 20 2
Trp L Met ML Ala S Asn MS
Val MS Cys MS Ser S Gln ML
Leu ML Pro MS Gly S Glu ML
Ile ML Tyr L His ML Asp MS
Phe L Thr MS Lys ML Arg L

The grouping is determined by equating van der Waals volumes >190 Å3 with large beads (L), 140–190 Å3 with medium-large beads (ML), 140–100 Å3 with medium-small beads (MS), and <100 Å3 with small beads (S). Volumes were taken from a study by Harpaz et al. (39).