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. Author manuscript; available in PMC: 2011 Jun 11.
Published in final edited form as: Circ Res. 2010 Apr 29;106(11):1743–1752. doi: 10.1161/CIRCRESAHA.110.219816

Figure 3. FKBP12.6-RyR2 association and resting RyR2 activity.

Figure 3

A, Time course of FKBP12.6 (100 nM) wash-in and influence of cAMP and rapamycin; B, Normalized FKBP12.6 and cAMP effects on CaSpF, FKBP12.6-RyR2 binding (n=25,17) & SR Ca load (assessed by 10mM caffeine, n=6). Basal control CaSpF is 8.7± 0.6 sparks (s-1 100μm-1). C, Normalized graph of rapamycin effects on CaSpF, FKBP12.6-RyR2 binding, and SR load (n=45,10,7). D-F, FKBP12.6, rapamycin & cAMP effects on Ca spark amplitude, width (FWHM) and duration (FDHM).