Table I.

miRNAs Aberrantly Expressed in Cancers

Cancer type	Upregulated	Downregulated	Reference
Breast cancer	miR-10b, miR-21, miR-22, miR-27a, miR-155, miR-210, miR-221, miR-222, miR-328, miR-373, miR-520c	let-7, miR-7, miR-9-1, miR-17/miR-20, miR-31, miR-125a, miR-125b, miR-146, miR-200 family, miR-205, miR-206, miR-335	(15–31)
CLL	miR-21,miR-155	miR-15, miR-16, miR-29b, miR-29c, miR-34a, miR-143, miR-145, miR-181b, miR-223	(11,32–36)
Lung cancer	miR-17-92 cluster, miR-21, miR-106a, miR-155	miR-1, let-7 family, miR-7, miR-15a/miR-16, miR-29 family	(12,22,37–40)
Lymphoma	miR-17-92 cluster, miR-155	miR-143, miR-145	(36,41,42)
Prostate cancer	miR-221, miR-222	miR-15a-miR-16-1 cluster, miR-101, miR-127, miR-449a	(43–47)
Glioblastoma	miR-21, miR-221, miR-222	miR-7	(22,48,49)
Hepatocellular carcinoma	miR-17-92 cluster, miR-21, miR-143, miR-224	miR-1, miR-101, miR-122a	(50–55)
Colorectal cancer	miR-17-92 cluster, miR-21	miR-34a, miR-34b/c, miR-127, miR-143, miR-145, miR-342	(46,56–60)
Gastric cancer	miR-21, miR-27a	miR-143, miR-145	(61–63)
Ovarian cancer	miR-214	miR-34b/c, miR-200 family	(64–66)
Melanoma	miR-221, miR-222	let-7a, miR-34a	(67–69)
Head and neck squamous cell carcinoma	miR-21	let-7d, miR-138, miR-205	(70–72)

CLL chronic lymphocytic leukemia, CNV copy number variation, CSDC2 cold-shock domain-containing protein C2, EBV Epstein–Barr virus, EMT epithelial-to-mesenchymal transformation, EZH2 enhancer of zeste homolog 2, HBV hepatitis B virus, LNA locked nucleic acid, miRISC microRNA-induced silencing complex, miRNA microRNA, miRNP microRNA-induced silencing complex, NPC nasopharyngeal carcinoma, NSCLC non-small-cell lung carcinoma, nt nucleotides, p53RE p53 response element, pRb retinoblastoma protein, pre-miRNA miRNA precursor, pri-miRNA primary miRNA transcript, PTC papillary thyroid carcinoma, RNAa RNA activation, RNP RISC-like ribonucleoprotein complex, SNP single nucleotide polymorphisms, TARBP2 TAR RNA-binding protein 2, UTR untranslated region