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Antinociception produced by TPI-1818-101 and 1818-109 in the mouse 55°C warm water tail-withdrawal test is dose- and time-dependent. a Time course of TPI 1818-101 antinociception. b Time course of TPI 1818-109 antinociception. c Dose–response lines of morphine, TPI 1818-101, and TPI 1818-109 given by i.p. injection 30 min before testing in the mouse 55°C tail-withdrawal assay. Points, 8–10 mice
