Table III.
Parameters for Characterizing Drug Release Curve
| Abbreviation, description | Equation | Function in DDSolver | Reference(s) |
|---|---|---|---|
| AUC, area under the dissolution curve |
|
DD_AUC | (47) |
| ABC, area between the drug dissolution curve and its asymptote |
|
DD_ABC | (48,49) |
| MRT, mean residence time of the drug substance molecules in the dosage form |
|
DD_MRT | (49) |
| MDT, mean dissolution time |
|
DD_MDT | (50,51) |
| VDT, variance of dissolution time |
|
DD_VDT | (50,51) |
| m k, moments of dissolution times of order k |
|
DD_MDTk | (33,50) |
| RD, relative dispersion of dissolution time, CV2 (coefficient of variation) |
|
DD_RD | (33,51) |
| DE, dissolution efficiency |
|
DD_DE | (52) |
n number of sampling points; t
i
ith time point; y
i percentage of drug dissolved at time t
i; M
last accumulative percentage of drug dissolved at the last time point; y percentage of drug dissolved at time t; 
time at the midpoint between i and i–1; ∆M
i additional amount of drug dissolved between i and i–1; k order of the moments of dissolution times; y
100 maximum percentage of drug dissolved over the time period 0−t