Table III.
Abbreviation, description | Equation | Function in DDSolver | Reference(s) |
---|---|---|---|
AUC, area under the dissolution curve | DD_AUC | (47) | |
ABC, area between the drug dissolution curve and its asymptote | DD_ABC | (48,49) | |
MRT, mean residence time of the drug substance molecules in the dosage form | DD_MRT | (49) | |
MDT, mean dissolution time | DD_MDT | (50,51) | |
VDT, variance of dissolution time | DD_VDT | (50,51) | |
m k, moments of dissolution times of order k | DD_MDTk | (33,50) | |
RD, relative dispersion of dissolution time, CV2 (coefficient of variation) | DD_RD | (33,51) | |
DE, dissolution efficiency | DD_DE | (52) |
n number of sampling points; t i ith time point; y i percentage of drug dissolved at time t i; M last accumulative percentage of drug dissolved at the last time point; y percentage of drug dissolved at time t; time at the midpoint between i and i–1; ∆M i additional amount of drug dissolved between i and i–1; k order of the moments of dissolution times; y 100 maximum percentage of drug dissolved over the time period 0−t