Table IV.
Parameters for Assessing the Difference Between Dissolution Profiles
| Abbreviation, description | Equation | Function in DDSolver | Reference(s) |
|---|---|---|---|
| f 1, difference factora |
|
DD_f1 | (6) |
| f 2, similarity factora |
|
DD_f2 | (6) |
| f 1’, difference factor modified by Costa P.a |
|
DD_f1cp | (13) |
| ξ 1, first-order Rescigno indexa, b |
|
DD_res1 | (7) |
| ξ 2, second-order Rescigno indexa, b |
|
DD_res2 | (7) |
| S d, difference in similarityc |
|
DD_Sd | (53) |
| D, sum of squared mean differencesd |
|
DD_D | (44,54) |
| D 1, mean distanced |
|
DD_D1 | (55,56) |
| D 2, mean squared distanced |
|
DD_D2 | (56) |
| D AUC, difference of area under the profilesd,e |
|
DD_DAUC | (56) |
| D ABC, area between the profilesd,e |
|
DD_DABC | (56) |
a R t, T t are the percentage dissolved of the reference and test profile, respectively, at time point t; n is the number of sampling points
b j is 1 and 2 for the first- (ξ 1) and second-order (ξ 2) Rescigno indexes, respectively
c n is the number of sampling points; AUCRt and AUCTt are the areas under the dissolution curves of the reference and test formulations, respectively, at time t
d
p is the number of sampling points; 
and 
are the mean dissolution values of the test and reference profiles respectively at the ith time point
e t i is the ith sampling time point