Table IV.
Abbreviation, description | Equation | Function in DDSolver | Reference(s) |
---|---|---|---|
f 1, difference factora | DD_f1 | (6) | |
f 2, similarity factora | DD_f2 | (6) | |
f 1’, difference factor modified by Costa P.a | DD_f1cp | (13) | |
ξ 1, first-order Rescigno indexa, b | DD_res1 | (7) | |
ξ 2, second-order Rescigno indexa, b | DD_res2 | (7) | |
S d, difference in similarityc | DD_Sd | (53) | |
D, sum of squared mean differencesd | DD_D | (44,54) | |
D 1, mean distanced | DD_D1 | (55,56) | |
D 2, mean squared distanced | DD_D2 | (56) | |
D AUC, difference of area under the profilesd,e | DD_DAUC | (56) | |
D ABC, area between the profilesd,e | DD_DABC | (56) |
a R t, T t are the percentage dissolved of the reference and test profile, respectively, at time point t; n is the number of sampling points
b j is 1 and 2 for the first- (ξ 1) and second-order (ξ 2) Rescigno indexes, respectively
c n is the number of sampling points; AUCRt and AUCTt are the areas under the dissolution curves of the reference and test formulations, respectively, at time t
d p is the number of sampling points; and are the mean dissolution values of the test and reference profiles respectively at the ith time point
e t i is the ith sampling time point