. 2010 May 12;12(3):407–416. doi: 10.1208/s12248-010-9197-x

Table I.

Pharmacokinetic Parameters Obtained from Fitting Data to a Mechanistic Toxicokinetic Model with Nonlinear Metabolism and Nonlinear Renal Elimination

Parameter	Units	Description	Final estimate (CV% for between-subject variability)
V _plasma	ml	Plasma volume	10.5^a
V _tissue1	ml	Volume of the first tissue compartment	75.9 (16%)
V _tissue2	ml	Volume of the second tissue compartment	26.8
V _kidney	ml	Kidney volume	4.0^a
V _ulf1	ml	Volume of the first ultrafiltrate compartment	3.0^a
V _ulf2	ml	Volume of the second ultrafiltrate compartment	1.0^a
CL _D	ml/min	Distributional clearance (tissue 1)	26.9
CL _D2	ml/min	Distributional clearance (tissue 2)	3.07
Q _R	ml/min	Renal blood flow	12.5^a
V _max,m	mg/min	Maximum metabolic elimination rate	0.581
K _m,m	mg/ml	Metabolic Michaelis-Menten constant	0.054
GFR	mg/min/kg	Glomerular filtration rate	10
V _max,R	mg/min	Maximum renal reabsorption rate	2.34
K _m,R	mg/ml	Renal reabsorption Michaelis-Menten constant	0.46
UF	ml/min	Urine flow	0.1^a (114%)
ε _plasma		Proportional error for plasma	2.5%
ε _urine		Proportional error for urine	46%
OBJ		Objective function	−578.4

^aParameter was fixed to physiological value