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. 2010 May 12;12(3):407–416. doi: 10.1208/s12248-010-9197-x

Table I.

Pharmacokinetic Parameters Obtained from Fitting Data to a Mechanistic Toxicokinetic Model with Nonlinear Metabolism and Nonlinear Renal Elimination

Parameter Units Description Final estimate (CV% for between-subject variability)
V plasma ml Plasma volume 10.5a
V tissue1 ml Volume of the first tissue compartment 75.9 (16%)
V tissue2 ml Volume of the second tissue compartment 26.8
V kidney ml Kidney volume 4.0a
V ulf1 ml Volume of the first ultrafiltrate compartment 3.0a
V ulf2 ml Volume of the second ultrafiltrate compartment 1.0a
CL D ml/min Distributional clearance (tissue 1) 26.9
CL D2 ml/min Distributional clearance (tissue 2) 3.07
Q R ml/min Renal blood flow 12.5a
V max,m mg/min Maximum metabolic elimination rate 0.581
K m,m mg/ml Metabolic Michaelis-Menten constant 0.054
GFR mg/min/kg Glomerular filtration rate 10
V max,R mg/min Maximum renal reabsorption rate 2.34
K m,R mg/ml Renal reabsorption Michaelis-Menten constant 0.46
UF ml/min Urine flow 0.1a (114%)
ε plasma Proportional error for plasma 2.5%
ε urine Proportional error for urine 46%
OBJ Objective function −578.4

aParameter was fixed to physiological value