Table II.

Changes in Plasma AUC (min mg/ml) and Time-averaged Renal Clearance (milliliter per minute) Based on Simulations of Competitive Inhibition of Renal Reabsorption Using the Mechanistic Toxicokinetic Model

			GHB+inhibitor
	GHB alone		R = 1		R = 10		R = 100
GHB dose (mg/kg)	AUC	CL R	AUC	CL R	AUC	CL R	AUC	CL R
200	29.3	0.197	27.4	0.319	21.0	0.921	14.4	2.394
400	83.0	0.331	76.2	0.447	56.6	0.968	37.5	2.159
600	133.3	0.540	124.6	0.636	96.1	1.072	63.6	2.100
1,000	208.2	0.823	198.8	0.902	165.2	1.244	117.1	2.060

Active renal reabsorption was described by Eq. 11 and parameters were fixed to those listed in Table I

AUC is the area under the plasma concentration versus time curve; CL _R is renal clearance; R is the [I]/K _i