Table III.

Changes in Plasma AUC and Time-averaged Renal Clearance (CL _R) in Rats Following Administration of GHB Alone (600 mg/kg) or in Combination with l-lactate (330 mg/kg iv Bolus Followed by 121 mg/kg/h iv Infusion)

	AUC (mg*min/ml)	CLR (ml/min)	Sleep Time (min)
GHB alone (N = 3)	131 ± 18.8	0.415 ± 0.06	126 ± 15.1
GHB + l-lactate (N = 5)	74.8 ± 9.4*	0.910 ± 0.10*	87.0 ± 11.1*

Results are presented as mean ± SD

AUC is the area under the plasma concentration versus time curve; CL _R is renal clearance; sleep time is defined as the time difference between loss of righting reflex and return of righting reflex (RRR-LRR)

*P < 0.05 when compared using a Student's t test