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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Curr Opin Hematol. 2009 May;16(3):202–208. doi: 10.1097/MOH.0b013e32832a07ff

Figure 2. Stimulation of VEGFR1 expression in normal microvascular endothelial cells is controlled by the VEGFR2/TEM8/β1 integrin complex.

Figure 2

Stimulation of microvascular endothelial cells with VEGF or adhesion to extracellular matrix activates the VEGFR2/TEM8/β1 integrin complex. This results in stimulation of VEGFR1 transcription via activation of NFAT, high level expression of VEGFR1 protein and reduced VEGF-dependent signaling through VEGFR2.