Figure 3. Math1 is required for the differentiation of intestinal stem cells into goblet cells on Notch signalling inhibition.

Immunohistochemical analysis of small intestine from Math1^LoxP/LoxP (a), Math1^LoxP/LoxP/AHCre mice after deletion of Math1 (b), Math1^LoxP/LoxP treated with dibenzazepine (DBZ) (30 μmol kg⁻¹) to block the Notch pathway (c) and Math1^LoxP/LoxP/AHCre mice after deletion of Math1 on induction of the Cre enzyme, followed by pharmacological disruption of the Notch signalling pathway using DBZ (d) with the intestinal stem cell-specific marker Olmf4 (blue), in combination with a PAS staining (magenta) for goblet cells. Scale bar is 100 μm.