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. Author manuscript; available in PMC: 2011 Jun 11.
Published in final edited form as: Circ Res. 2010 Apr 15;106(11):1722–1730. doi: 10.1161/CIRCRESAHA.109.214353

Figure 4. Activation of mitochondrial biogenesis by EPO is dependent on Akt and eNOS.

Figure 4

A. Cardiac mRNA expression for NRF-1 and PGC-1α in Wt mice at day 3 post-EPO is absent in eNOS -/- and Akt1-/- mice. B. Increases in Tfam mRNA and mtDNA copy number in Wt mice at day 3 post-EPO is absent in eNOS -/- and Akt1-/- mice. C. SOD2 mRNA expression in Wt mouse heart pre- and post- EPO (left), and pre- and at post-EPO day 3 in Wt, eNOS -/- and Akt1-/- mice relative to GAPDH (right) (* P<0.05 vs. control; n=4).