Figure 3.

Histopathology of the periodontium of rats submitted to EPD and treated with venlafaxine. Venlafaxine (10 mg/kg) was administered orally 1 hour before ligature placement and daily for 10 days). Photomicrographs show the region between the first and second molars of rats: A) sham operated (SO) normal periodontium, where gingival (g), periodontal ligament (pl), alveolar bone (ab), cementum (c), B) periodontium of rat subjected to EPD showing inflammatory cell infiltration with severe cementum destruction and alveolar process, C) periodontium of rat with EPD and treated with venlafaxine showing no evidence of prevention of inflammation or bone resorption (arrow). H&E stain; original magnification × 40. Scale bars = 100 μm.