Table 2.
Relationship of SPARC expression in colon cancer tissues with clinicopathological parameters
| Tumors cell | MSC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameters | low reactivity high reactivity | P value | low reactivity high reactivity | P value | |||||||
| n | % | n | % | n | % | n | % | ||||
| Agea | 0.379 | 0.904 | |||||||||
| < 59 | 48 | 32 | 66.7 | 16 | 33.3 | 26 | 54.2 | 22 | 45.8 | ||
| ≥ 59 | 66 | 49 | 74.2 | 17 | 25.8 | 35 | 53.0 | 31 | 47.0 | ||
| Gender | 0.276 | 0.276 | |||||||||
| men | 54 | 41 | 75.9 | 13 | 24.1 | 26 | 48.1 | 28 | 51.9 | ||
| women | 60 | 40 | 66.7 | 20 | 33.3 | 35 | 58.3 | 25 | 41.7 | ||
| Tumor sizeb | 0.222 | 0.658 | |||||||||
| < 5.0 | 52 | 34 | 65.4 | 18 | 34.6 | 29 | 55.8 | 23 | 44.2 | ||
| ≥ 5.0 | 62 | 47 | 75.8 | 15 | 24.2 | 32 | 51.6 | 30 | 48.4 | ||
| Localization | 0.140 | 0.926 | |||||||||
| colon ascendens | 27 | 22 | 81.5 | 5 | 18.5 | 14 | 51.9 | 13 | 48.1 | ||
| flexura hepatica | 22 | 17 | 77.3 | 5 | 22.7 | 12 | 54.5 | 10 | 45.5 | ||
| colon transversum | 6 | 6 | 100 | 0 | 0 | 3 | 50.0 | 3 | 50.0 | ||
| flexura lienalis | 8 | 6 | 75.0 | 2 | 25.0 | 3 | 37.5 | 5 | 62.5 | ||
| colon descendens | 6 | 3 | 50.0 | 3 | 50.0 | 4 | 66.7 | 2 | 33.3 | ||
| colon sigmoideum | 45 | 27 | 60.0 | 18 | 40.0 | 25 | 55.6 | 20 | 44.4 | ||
| Tumor differentiation | 0.930 | 0.046 | |||||||||
| low | 16 | 12 | 75.0 | 4 | 25.0 | 4 | 25.0 | 12 | 75.0 | ||
| moderate | 68 | 48 | 70.6 | 20 | 29.1 | 39 | 57.4 | 29 | 42.6 | ||
| high | 30 | 21 | 70.0 | 9 | 30.0 | 18 | 60.0 | 12 | 40.0 | ||
| Lymph node metastasis | 0.462 | 0.013 | |||||||||
| N0 | 65 | 44 | 67.7 | 21 | 32.3 | 28 | 43.1 | 37 | 56.9 | ||
| N1 | 36 | 26 | 72.2 | 10 | 27.8 | 22 | 61.1 | 14 | 38.9 | ||
| N2 | 13 | 11 | 84.6 | 2 | 15.4 | 11 | 84.6 | 2 | 15.4 | ||
| R/DMc | 0.490 | 0.746 | |||||||||
| Yes | 23 | 15 | 65.2 | 8 | 34.8 | 13 | 56.5 | 10 | 43.5 | ||
| No | 91 | 66 | 72.5 | 25 | 27.5 | 48 | 52.7 | 43 | 47.3 | ||
| L/infiltrationd | 0.626 | 0.678 | |||||||||
| Yes | 41 | 28 | 68.3 | 13 | 21.7 | 23 | 56.1 | 18 | 43.9 | ||
| No | 73 | 53 | 72.6 | 20 | 27.4 | 38 | 52.1 | 35 | 47.9 | ||
| depth of invasion | 0.459 | 0.850 | |||||||||
| T2 | 15 | 12 | 80.0 | 3 | 20.0 | 8 | 53.3 | 7 | 46.7 | ||
| T3 | 88 | 60 | 68.2 | 28 | 31.8 | 48 | 54.5 | 40 | 45.5 | ||
| T4 | 11 | 9 | 81.8 | 2 | 18.2 | 5 | 45.5 | 6 | 54.5 | ||
| Distant metastasis | 0.504 | 0.797 | |||||||||
| M0 | 102 | 71 | 69.6 | 31 | 30.4 | 55 | 53.9 | 47 | 46.1 | ||
| M1 | 12 | 10 | 83.3 | 2 | 16.7 | 6 | 50.0 | 6 | 50.0 | ||
| TNM staging | 0.431 | 0.297 | |||||||||
| I | 11 | 9 | 81.8 | 2 | 22.2 | 5 | 45.5 | 6 | 54.5 | ||
| II | 47 | 30 | 63.8 | 17 | 36.2 | 21 | 44.7 | 26 | 55.3 | ||
| III | 44 | 32 | 72.7 | 12 | 27.3 | 28 | 63.6 | 16 | 36.4 | ||
| IV | 12 | 10 | 83.3 | 2 | 16.7 | 7 | 58.3 | 5 | 41.7 | ||
a median, 59 years; b mean, 5.0 cm; c R/DM-Recurrence/distant metastasis;
d lymphocytic infiltration in the tumor interstitial