Table 3.

The association between rs702553 at the PDE4D gene and carotid atherosclerosis

Atherosclerotic risk	Overall			Men			Women
	AA + AT	TT	statistics	AA + AT	TT	statistics	AA + AT	TT	statistics
Carotid plaque	N = 544	N = 108		N = 216	N = 40		N = 328	N = 68
No plaque (index = 0)	354 (83.7%)	69 (16.3%)	ref.	129 (86.6%)	20 (13.4%)	ref.	225 (82.1%)	49 (17.9%)	ref.
Low-risk (index = 1-3)	163 (84.5%)	30 (15.5%)	OR = 1.0 (0.6-1.7) p = 0.934	66 (84.6%)	12 (15.4%)	OR = 1.5 (0.7-3.6) p = 0.312	97 (84.3%)	18 (15.7%)	OR = 0.8 (0.4-1.5) P = 0.534
High-risk (index ≥ 4)	27 (75.0%)	9 (25.0%)	OR = 3.1 (1.1-8.7) p = 0.034	21 (72.4%)	8 (27.6%)	OR = 5.9 (1.6-21.5) p = 0.008	6 (85.7%)	1 (14.3%)	OR = NA
Age-adjusted IMT(mm)	N = 775	N = 162		N = 367	N = 76		N = 408	N = 86
CCA	0.61 ± 0.12	0.62 ± 0.11	p = 0.150	0.63 ± 0.14	0.66 ± 0.13	p = 0.041	0.59 ± 0.10	0.59 ± 0.08	p = 0.862
Bif	0.65 ± 0.12	0.66 ± 0.13	p = 0. 396	0.67 ± 0.12	0.70 ± 0.14	p = 0.068	0.63 ± 0.11	0.62 ± 0.09	p = 0.472
ICA	0.51 ± 0.10	0.51 ± 0.11	p = 0.518	0.53 ± 0.11	0.55 ± 0.13	p = 0.111	0.48 ± 0.08	0.48 ± 0.08	p = 0.441
Dichotomized IMT (advanced atherosclerotic group(> mean + 1SD)
CCA	98 (12.7%)	23 (14.5%),	OR = 1.2 (0.7-1.9) p = 0.584	43 (11.7%)	17(22.4%)	OR = 2.1 (1.1-4.1) p = 0.032	55 (13.5%)	6 (7.2%)	OR = 0.5 (0.2-1.2) p = 0.109
Bif	110 (14.2%)	30 (18.9%),	OR = 1.5 (0.9-2.3) p = 0.099	53 (14.5%)	17 (22.4%)	OR = 1.8 (0.9-3.3) p = 0.078	57 (14.0%)	13 (15.7%)	OR = 1.1 (0.6-2.2) p = 0.686
ICA	96 (12.5%)	20 (12.7%),	OR = 1.0 (0.6-1.7) p = 0.940	36 (9.9%)	7 (9.2%)	OR = 0.8 (0.3-1.9) p = 0.588	60 (14.8%)	13 (16.0%)	OR = 1.1 (0.6-2.2) p = 0.724

OR (95% confidence interval) was obtained from logistic regression with adjustment of age, hypertension, diabetes, hyperlipidemia and smoking.

Age-adjusted IMT was presented as mean ± SD