Table 2. Association statistics of SNPs in genes previously reported to associate with susceptibility to leprosy.
Chr | Gene | No. of SNPs | Best SNP | OR | 95% CI | P-value | Bonferroni P-value |
1 | IL10 | 13 | rs1554286 | 1.52 | 1.15–1.99 | 0.003 | 0.039 |
2 | SLC11A1 | 9 | rs13062 | 1.39 | 1.03–1.88 | 0.032 | 0.288 |
4 | TLR2 | 8 | rs1339 | 0.72 | 0.47–1.09 | 0.116 | 0.928 |
5 | IL12B | 15 | rs919766 | 2.82 | 1.22–6.52 | 0.011 | 0.165 |
6 | MICA | 13 | rs12660741 | 2.15 | 1.45–3.18 | 9.9×10−5 | 0.001 |
6 | MICB | 8 | rs3828917 | 0.32 | 0.16–0.66 | 0.001 | 0.008 |
6 | LTA | 15 | rs1121800 | 1.20 | 0.92–1.56 | 0.19 | 1.000 |
6 | TNF | 15 | rs3093662 | 0.29 | 0.13–0.63 | 3.2×10−4 | 0.005 |
6 | PARK2 [10] | 2 | rs6455767 | 0.73 | 0.46–1.15 | 0.177 | 0.354 |
6 | PACRG [10] | 1 | rs9458710 | 1.27 | 0.68–2.36 | 0.454 | 0.454 |
9 | TLR4 | 28 | rs7044464 | 1.57 | 1.05–2.35 | 0.029 | 0.812 |
12 | VDR | 62 | rs2254210 | 0.60 | 0.41–0.88 | 0.008 | 0.496 |
16 | NOD2 [27] | 27 | rs4785224 | 0.65 | 0.46–0.92 | 0.012 | 0.324 |
19 | IL12RB1 | 9 | rs436857 | 0.77 | 0.51–1.16 | 0.207 | 1.000 |
This table shows the number of SNPs and the best SNP in each gene, with the Bonferroni P-value corrected with the number of SNPs in the region. Results previously presented are referenced as denoted.