Table 4.

Multivariable regression analyses for the association of the sensitive periodsframework of life course socioeconomic position with concentrations of inflammatory markers

	Model Adjustment
	Age, sex	Age, Sex, Other SEP Measures^†	Age, Sex, CHD Risk Markers^‡	Age, Sex, Other SEP Measures^†, CHD Risk Markers^‡

Inflammatory Marker	β ^*	β	β	β
Father’s Education
CRP,ln mg/L	0.163(0.023,0302)	0.098(−0.048,0.244)	0.017(−0.108,0.142)	−0.008(−0.138,0.121)
IL-6,ln pg/mL	0.067(−0.021,0.155)	0.031(−0.060,0.123)	−0.002(−0.086,0.082)	−0.015(−0.102,0.072)
ICAM-1, lnng/mL	0.038(0.006,0.070)	0.020(−0.014,0.055)	0.009(−0.021,0.039)	0.002(−0.030,0.033)
TNFR2, ln pg/mL	0.055(0.018,0.093)	0.044(0.004,0.084)	0.028(−0.009,0.064)	0.019(−0.020,0.058)
Lp-PLA₂, lnnmol/min/mL	0.036(0.005,0.068)	0.030(−0.003,0.063)	0.004(−0.025,0.032)	0.000(−0.030,0.030)
P-Selectin, lnng/mL	0.003(−0.044,0.050)	−0.014(−0.063,0.036)	−0.027(−0.074,0.020)	−0.033(−0.082,0.015)
MCP-1, ln pg/mL	0.016(−0.029,0.061)	−0.009(−0.058,0.039)	−0.003(−0.043,0.049)	−0.015(−0.064,0.034)
Fibrinogen, ln g/L	0.017(−0.007,0.041)	0.010(−0.014,0.035)	−0.005(−0.027,0.017)	−0.008(−0.031,0.015)

Own Education
CRP,ln mg/L	0.336(0.179, 0.494)	0.249(0.072,0.426)	0.149(0.010,0.288)	0.111(−0.063,0.286)
IL-6,ln pg/mL	0.148(0.051, 0.245)	0.102(−0.010,0.214)	0.049(−0.045,0.142)	0.028(−0.081,0.137)
ICAM-1, lnng/mL	0.064(0.030, 0.098)	0.040(0.002,0.079)	0.027(−0.005,0.058)	0.013(−0.023,0.049)
TNFR2, ln pg/mL	0.048(0.009, 0.088)	0.012(−0.032,0.056)	0.025(−0.014,0.064)	−0.004(−0.048,0.040)
Lp-PLA₂, lnnmol/min/mL	0.024(−0.008, 0.055)	0.010(−0.027,0.046)	−0.000(−0.030,0.029)	−0.013(−0.048,0.022)
P-Selectin, lnng/mL	0.073(0.023, 0.123)	0.071(0.014,0.128)	0.034(−0.016,0.084)	0.037(−0.019,0.093)
MCP-1, ln pg/mL	0.062(0.013, 0.111)	0.071(0.018,0.124)	0.039(−0.012,0.089)	0.052(−0.002,0.106)
Fibrinogen, ln g/L	0.037(0.012, 0.062)	0.031(0.003,0.060)	0.015(−0.009,0.039)	0.014(−0.013,0.042)

Own Occupation
CRP,ln mg/L	0.221(0.066, 0.375)	0.123(−0.049,0.296)	0.167(0.028,0.307)	0.150(−0.004,0.304)
IL-6,ln pg/mL	0.124(0.026, 0.223)	0.087(−0.024,0.198)	0.065(−0.027,0.158)	0.065(−0.040,0.170)
ICAM-1, lnng/mL	0.057(0.022, 0.093)	0.039(−0.001,0.079)	0.032(−0.001,0.066)	0.029(−0.008,0.066)
TNFR2, ln pg/mL	0.076(0.037, 0.114)	0.064(0.023,0.106)	0.070(0.031,0.109)	0.069(0.026,0.111)
Lp-PLA₂, lnnmol/min/mL	0.019(−0.013, 0.050)	0.008(−0.027,0.0432)	0.027(−0.003,0.057)	0.030(−0.004,0.064)
P-Selectin, lnng/mL	0.029(−0.020, 0.077)	0.012(−0.040,0.064)	0.017(−0.030,0.063)	0.017(−0.033,0.067)
MCP-1, ln pg/mL	0.024(−0.025, 0.073)	−0.006(−0.056,0.045)	0.007(−0.045,0.058)	0.015(−0.067,0.038)
Fibrinogen, ln g/L	0.020(−0.006, 0.046)	0.009(−0.020,0.038)	0.013(−0.011,0.038)	0.012(−0.016,0.039)

For father’s education, regression coefficients (β) represent the relative logarithmic change in biomarker units (95% confidence intervals) for participants with father’s education of <high school, versus father’s education of >high school. Multivariable regressions included category of high school education (results not shown). For own education, regression coefficients (β) represent the relative logarithmic change in biomarker units (95% confidence intervals) for participants with own education of ≤12 years, versus own education of >16 years. For ownoccupation, regression coefficients (β) represent the relative logarithmic change in biomarker units (95% confidence intervals) for laborers versus participants with supervisory/technical/professional/executive jobs.

^†

Other SEP measures correspond to the two SEP variables other than the independent variable. For example, if father’s education is the independent variable, other SEP measures would include own education and occupation.

^‡

CHD risk markers include smoking, body mass index, systolic blood pressure, total:HDL cholesterol ratio, fasting glucose, cholesterol-lowering medication use, anti-hypertensive medication use and depressive symptomatology.