Fig. 2.

a–f Hazelnut elicits an IgE response that is characterized by long-lasting memory in BALB/c mice. Groups of mice (n = 10/group) were transdermally exposed to hazelnut protein (0 or 1 mg/mouse), and then allergen was withdrawn as described in the Methods. Then mice were given two booster transdermal exposures, and their memory IgE levels were measured. a, b Three-month allergen withdrawal experiment. c, d Five-month allergen withdrawal experiment. e, f Eight-month allergen withdrawal experiment. Data shown as means ± SE. Unpaired t test results: * p < 0.05.