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. Author manuscript; available in PMC: 2011 Jun 24.
Published in final edited form as: J Med Chem. 2010 Jun 24;53(12):4731–4748. doi: 10.1021/jm1003232

Figure 1.

Figure 1

Specific 86Rb+ efflux (ordinate; percentage of control) was determined for functional, human muscle-type α1β1γδ-nAChR (●), ganglionic α3β4*-nAChR (○), α4β2-nAChR (▲) or α4β4-nAChR (▽) naturally or heterologously expressed in human cell lines in the presence of a receptor subtype-specific, EC80-EC90 concentration of the full agonist, carbamylcholine, either alone or in the presence of the indicated concentrations (abscissa, log molar) of (2S,3S)-hydroxybupropion [(2S,3S)-4a] or its analogues (compounds 4d, 4c, and 4g) as indicated. Mean micromolar IC50 values and SEM as a multiplication/division factor of the mean micromolar IC50 value are provided in Table 1.