Figure 6. IL-1R1 is required for inhibition of Shh by IL-1β.

Co-localization of H, K-ATPase (green) (A) and IL-1β receptor1 (red) (B). (C) Quantitative RT-PCR was performed on RNA extracted from organ cultures isolated from gastric corpus of PBS-treated (open bars) or IL-1β-treated (black bars) stomachs isolated from WT or IL-1R1KO mice and treated with PBS (grey bar) or IL-1β (black bar). Shown is the ratio of Shh to GAPDH mRNA expressed as the mean ± SEM for four mice. *P < 0.05 compared with vehicle treated mice. NS, not statistically significant.