Table 4.
Fold-elevation in the infected group, cutoff values, specificity, sensitivity, positive predictive value, negative predictive value and accuracy are listed for 6 biomarkers
| Biomarker or variable | Fold-elevation | Cutoff value | Spec. | Sens. | PPV | NPV | ACC |
|---|---|---|---|---|---|---|---|
| IL-1b | 258 | 112 pg/ml | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| IL-6 | 27 | 13350 pg/ml | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| G-CSF | 120 | 35 pg/ml | 0.95 | 1.00 | 0.88 | 1.00 | 0.96 |
| IL-1a | 24 | 1 pg/ml | 0.97 | 0.86 | 0.92 | 0.95 | 0.94 |
| IL-17 | 112 | 7.2 pg/ml | 0.97 | 0.86 | 0.92 | 0.95 | 0.94 |
| SKALP | 2 | 1880 pg/ml | 0.89 | 0.79 | 0.73 | 0.92 | 0.86 |
| SF WBC | 31 | 2000 cells/mm3 | 0.84 | 0.93 | 0.68 | 0.97 | 0.86 |
| CRP | 13 | 10 mg/l | 0.86 | 0.71 | 0.67 | 0.89 | 0.82 |
| % Segs | 2 | 65 | 0.73 | 1.00 | 0.58 | 1.00 | 0.80 |
| ESR | 3 | 30 mm/hr | 0.73 | 0.86 | 0.55 | 0.93 | 0.76 |
Spec = specificity; Sens = sensitivity; PPV = positive predictive value; NPV = negative predictive value; ACC = accuracy; SF WBC = synovial fluid white blood cell count; CRP = C-reactive protein; % segs = percent segmented neutrophils; ESR = erythrocyte sedimentation rate.