Table 2.
Demographic characteristics of culture-negative and culture-positive PJIs seen at the Mayo Clinic between 1985 and 2000
| Demographic characteristics | Culture-negative (N = 135) | Culture-positive (N = 135) |
|---|---|---|
| Prosthesis location | N (%) | N (%) |
| Hip | 68 (50%) | 68 (50%) |
| Knee | 67 (50%) | 67 (50%) |
| Median age, years (range) | 68.9 (17–88) | 71.3 (35–93) |
| Gender | ||
| Male | 71 (53%) | 71 (53%) |
| Female | 64 (47%) | 64 (47%) |
| Median joint age, days (range) | 746 (4–8882) | 588 (9–8195) |
| Underlying native joint disease | ||
| Degenerative joint disease | 72 (53%) | 93 (67%) |
| Rheumatic disease | 20 (15%) | 24 (18%) |
| Avascular necrosis | 4 (3%) | 1 (0.7%) |
| Sepsis | 6 (4%) | 3 (2%) |
| Neoplasia | 3 (2%) | 0 (0%) |
| Congenital | 6 (4%) | 9 (7%) |
| Miscellaneous | 23 (17%) | 5 (3,7%) |
| Prior diagnosis of PJI | 25 (19%) | 11 (8%) |
| Median number of prior implants (range) | 1.377 (1–8) | 1.629 (1–7) |
| Onset of symptoms | ||
| Pain | 118 (87%) | 125 (93%) |
| Fever | 21 (16%) | 29 (22%) |
| Local symptoms* | 72 (53%) | 68 (50%) |
| Surgical therapy | ||
| Staged therapy† | 56 (42%) | 67 (49%) |
| Resection arthroplasty | 34 (25%) | 30 (22%) |
| Débridement and components retention | 18 (13%) | 15 (11%) |
| Amputation | 5 (4%) | 0 (0%) |
| One-stage exchange | 8 (6%) | 10 (7%) |
| No therapy | 1 (0.7%) | 7 (5%) |
| Chronic suppression | 13 (10%) | 6 (4%) |
| Duration of parenteral antimicrobial therapy in days (range) | 22 (0–136 days) | 28 (0–95) |
| Duration of prior antimicrobial therapy in days (range) | 34.5 (1–2600) | 18 (1–94) |
| Complication with antimicrobial therapy | 11 (8%) | 2 (2%) |
* Redness swelling, warmth; †including two and more staged surgeries; PJI = prosthetic joint infection.