Table 1.
The table shows comparison of the results reported by studies based on poragen fraction and type
| Study | Year | Poragen | Poragen fraction | Result |
|---|---|---|---|---|
| (1) Does poragen fraction change antimicrobial release? | ||||
| Hanssen and Spangehl [7] | 2004 | Multiple different antimicrobials | N/A | increasing dose of antimicrobials increases amtimicrobial delivery to the patient |
| Keuchle et al. [11] | 1999 | Dextran | 25 wt% | 25% dextran increases antimicrobial delivery |
| McLaren et al. [18] | 2006 | Xylitol, glycine | 32 vol% | 28 g of xylitol or glycine both increase porosity; porosity increase was greater for xylitol than glycine |
| McLaren et al. [17] | 2007 | Xylitol | 32 vol% | sucrose and xylitol causes similar increase in porosity when controlled for particle size |
| McLaren et al. [16] | 2007 | Sucrose, xylitol, erythritol | 32 vol% | all three fillers increase porosity of PMMA |
| Nugent et al. [current study] | 2009 | Xylitol | 0.75, 1.50, 3, 5.75, 11 vol% | xylitol (100–200 μm particle size) produced porosity leading to dose dependent increased antimicrobial delivery |
| (2) Does poragen fraction change compressive strength? | ||||
| Lautenschlager et al. [12] | 1976 | Gentamicin sulfate | 0, 3, 7, 14 wt% | gentamicin sulfate caused dose dependent loss in compressive strength but elution did not decrease strength. |
| Lewis and Bhattaram [13] | 2006 | Gentamicin sulfate | 4.22 wt% | low dose ALBC did not decrease mechanical properties for multiple different t cements |
| Nugent et al. [current study] | 2009 | Xylitol | 0.75, 1.50, 3, 5.75, 11 vol% | increasing amounts of xylitol caused dose dependant decrease in compressive strength |
| (3) Does the effect of poragen fraction on compressive strength change over time? | ||||
| Lewis and Janna [14] | 2006 | Gentamicin | 2.2, 4.25, 11/50 wt% | increasing antibiotic load causes a dose dependent reduction in fatigue life under elution |
| He et al. [8] | 2002 | Gentamicin | 0, 1.7, 3.4, 6.5, 9.4 wt% | above 3–4 wt%, compressive strength decreases with time in elution |
| Nugent et al. [current study] | 2009 | Xylitol | 0.75, 1.50, 3, 5.75, 11 vol% | increasing poragen fraction caused dose dependent loss of compressive strength and that loss of compressive strength progressed with time in elution |