Table 3.

Course of tender joint count, swollen joint count, erythrocyte sedimentation rate, and C-reactive protein (effectiveness population)

	TJC (mean ± SD)	SJC (mean ± SD)	ESR (mm/h, mean ± SD)	CRP (mg/L, mean ± SD)
Baseline	10.1 ± 6.6	8.1 ± 5.7	39.7 ± 22.4	37.7 ± 80.5
Week 12	5.7 ± 5.4	4.1 ± 4.2	26.1 ± 19.4	Not done
Week 24	3.9 ± 4.7	2.6 ± 3.6	23.2 ± 17.2	13.2 ± 22.4
Difference week 24–baselinea	-6.6 ± 6.6	-5.8 ± 5.6	-17.7 ± 23.1	-26.8 ± 70.6
P value for changesb	<0.001	<0.001	<0.001	<0.001

CRP C-reactive protein, ESR erythrocyte sedimentation rate, SD standard deviation, SJC swollen joint count, TJC tender joint count

^aEndpoint analysis, i.e., only patients considered with data both for baseline and week 24

^bWilcoxon signed rank test