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. Author manuscript; available in PMC: 2010 Jul 2.
Published in final edited form as: Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):608–619. doi: 10.1080/15257770802138558

FIGURE 2.

FIGURE 2

Uric acid induces production of reactive oxygen species in human subcutaneous primary adipocytes. Treatment with uric acid and inhibitors were performed as described in Figure 1. (A) ROS-induced fluorescence is shown in the left panels; images of the adipocytes by differential interference contrast (DIC) are shown in the right panels. (B) The effect of uric acid is blocked by the superoxide scavenger MnTMPyP and an inhibitor of NADPH oxidase apocynin. *— the effect of uric acid is significant (P < 0.05, nonparametric U-test); and — the effect of the inhibitor is significant (P < 0.05, U-test, n = 3).