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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Inflamm Bowel Dis. 2010 May;16(5):736–742. doi: 10.1002/ibd.21144

Figure 4.

Figure 4

Secretion of HNP-1 after MDP stimulation is abrogated with NOD2 3020insC mutant CD associated. (A) Effect of hnp-1 or nod2 siRNA on human HNP-1 peptide release in HCT116 and Caco-2 cells 18 h after MDP-LD stimulation. (B) Caco-2 cells were transfected with DNA encoding NOD2 wild-type and DNA encoding the NOD2 3020insC CD associated mutant. After transfection, cells were stimulated with 1 μg of MDP-LD and HNP-1 peptide secretion was measured in the cell culture supernatants 18 h later by ELISA. *p<0.05